Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation.
Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation.
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DOI：
10.3389/fimmu.2012.00298
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发表时间：
2012
影响因子：
7.3
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Recchiuti A;Serhan CN
未解决的炎症与几种广泛发生的疾病有关，如关节炎、牙周病、癌症和动脉粥样硬化。内源性机制，减少过度炎症和促进其及时解决是相当大的兴趣。近年来，以前未被识别的化学介质，来自多不饱和脂肪酸被确定为控制急性炎症反应，通过激活局部解决方案。其中包括所谓的特化促消退脂质介质（SPM），其包括脂氧素（LX）、消退素（Rv）、保护素（PD）和maresins（MaR），因为它们在自限性炎症消退期间酶促生物合成。它们各自具有不同的化学结构，并通过其以立体特异性方式激活促分辨G蛋白偶联受体（GPCR）的能力来调节细胞途径。例如，RvD1控制自限性急性炎症中的几种感兴趣的miRNA，这些miRNA反调节参与炎症的介质和蛋白质。在这里，我们概述了SPM作用的一些生物合成和机制，重点是最近报道的miR参与其促消退反应，强调其在急性炎症调节及其及时消退中的有益作用。这些机制在体内发挥作用，将急性炎症保持在生理界限内，并刺激消退，这些机制的阐明开辟了消退药理学和许多新的机会，通过激活消退机制靶向炎症相关的人类病理学。
Unresolved inflammation is associated with several widely occurring diseases such as arthritis, periodontal diseases, cancer, and atherosclerosis. Endogenous mechanisms that curtail excessive inflammation and prompt its timely resolution are of considerable interest. In recent years, previously unrecognized chemical mediators derived from polyunsaturated fatty acids were identified that control the acute inflammatory response by activating local resolution programs. Among these are the so-called specialized pro-resolving lipid mediators (SPMs) that include lipoxins (LX), resolvins (Rv), protectins (PD), and maresins (MaR), because they are enzymatically biosynthesized during resolution of self-limited inflammation. They each possess distinct chemical structures and regulate cellular pathways by their ability to activate pro-resolving G-protein coupled receptors (GPCRs) in a stereospecific manner. For instance, RvD1 controls several miRNAs of interest in self-limited acute inflammation that counter-regulate the mediators and proteins that are involved in inflammation. Here, we overview some of the biosynthesis and mechanisms of SPM actions with focus on the recently reported miR involved in their pro-resolving responses that underscore their beneficial actions in the regulation of acute inflammation and its timely resolution. The elucidation of these mechanisms operating in vivo to keep acute inflammation within physiologic boundaries as well as stimulate resolution have opened resolution pharmacology and many new opportunities to target inflammation-related human pathologies via activating resolution mechanisms.
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影响因子：
64.8
作者：
Chiang, Nan;Fredman, Gabrielle;Backhed, Fredrik;Oh, Sungwhan F.;Vickery, Thad;Schmidt, Birgitta A.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
DOI：
10.1016/j.bbalip.2010.08.002
发表时间：
2010-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bannenberg G;Serhan CN
通讯作者：
Serhan CN
影响因子：
7.3
作者：
Chiang, N;Takano, T;Serhan, CN
通讯作者：
Serhan, CN
DOI：
10.1073/pnas.0405445101
发表时间：
2004-10-19
影响因子：
11.1
作者：
Chiang, N;Bermudez, EA;Serhan, CN
通讯作者：
Serhan, CN
影响因子：
4.4
作者：
Arita, Makoto;Ohira, Taisuke;Serhan, Charles N.
通讯作者：
Serhan, Charles N.