Specialized pro-resolving lipid mediators in the inflammatory response: An update.
Specialized pro-resolving lipid mediators in the inflammatory response: An update.
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DOI：
10.1016/j.bbalip.2010.08.002
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Bannenberg G;Serhan CN
一种新的专门促消退介质（SPM），包括几个不同的局部介质（脂氧素，消退素，保护素和maresins）家族，积极参与炎症渗出物的清除和调节，以恢复组织稳态。时间调节的经典脂质介质由花生四烯酸形成，并且发现了由ω-3多不饱和脂肪酸（例如二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸）生物合成的新型局部介质。消退素的生物合成途径由脂肪酸脂氧合酶和环氧合酶-2通过由从脉管系统迁移到发炎组织部位的先天免疫效应细胞建立的跨细胞相互作用构成。SPM提供了对炎症反应的执行的局部控制，并包括最近认识到的SPM的作用，如组织保护和宿主防御。SPM的结构家族不类似于经典的类花生酸（PG或LT），而是通过前分辨细胞和分子靶点发挥独特功能的新结构。表达SPM生物合成途径的炎性细胞的外渗与作为SPM形成底物所需的来自循环的必需脂肪酸的时间供应相匹配。本综述提供了一个更新和概述的SPM的生物合成途径和行动，并检查决议作为炎症反应的一个组成部分，并通过生化活性的决议机制恢复到稳态。
A new genus of specialized pro-resolving mediators (SPM) which include several families of distinct local mediators (lipoxins, resolvins, protectins, and maresins) are actively involved in the clearance and regulation of inflammatory exudates to permit restoration of tissue homeostasis. Classic lipid mediators that are temporally regulated are formed from arachidonic acid, and novel local mediators were uncovered that are biosynthesized from ω-3 poly-unsaturated fatty acids, such as eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid. The biosynthetic pathways for resolvins are constituted by fatty acid lipoxygenases and cyclooxygenase-2 via transcellular interactions established by innate immune effector cells which migrate from the vasculature to inflamed tissue sites. SPM provide local control over the execution of an inflammatory response towards resolution, and include recently recognized actions of SPM such as tissue protection and host defense. The structural families of the SPM do not resemble classic eicosanoids (PG or LT) and are novel structures that function uniquely via proresolving cellular and molecular targets. The extravasation of inflammatory cells expressing SPM biosynthetic routes are matched by the temporal provision of essential fatty acids from circulation needed as substrate for the formation of SPM. The present review provides an update and overview of the biosynthetic pathways and actions of SPM, and examines resolution as an integrated component of the inflammatory response and its return to homeostasis via biochemically active resolution mechanisms.
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DOI：
10.1111/j.1749-6632.2008.03975.x
发表时间：
2009-01-01
期刊：
NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY
影响因子：
--
作者：
Berczi, Istvan;Quintanar-Stephano, Andres;Kovacs, Kalman
通讯作者：
Kovacs, Kalman
DOI：
10.1073/pnas.0405445101
发表时间：
2004-10-19
影响因子：
11.1
作者：
Chiang, N;Bermudez, EA;Serhan, CN
通讯作者：
Serhan, CN
影响因子：
4.8
作者：
Biteman, Benjamin;Hassan, Iram R.;Gronert, Karsten
通讯作者：
Gronert, Karsten
影响因子：
15.9
作者：
COLGAN, SP;SERHAN, CN;MADARA, JL
通讯作者：
MADARA, JL
影响因子：
6.5
作者：
Bouvier, Jerome;Berry, Karin A. Zemski;Delton-Vandenbroucke, Isabelle
通讯作者：
Delton-Vandenbroucke, Isabelle