Lewy body‐related α‐synucleinopathy in the spinal cord of cases with incidental Lewy body disease
Lewy body‐related α‐synucleinopathy in the spinal cord of cases with incidental Lewy body disease
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偶发路易体病病例脊髓中路易体相关的 α-突触核蛋白病
DOI：
10.1111/j.1440-1789.2011.01211.x
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发表时间：
2012
期刊：
影响因子：
2.3
通讯作者：
G. Sobue
中科院分区：
文献类型：
--
作者：
T. Tamura;Mari Yoshida;Y. Hashizume;G. Sobue
偶发性路易体病 (ILBD) 代表路易体病 (LBD) 的早期无症状阶段，包括特发性帕金森病 (PD)。尽管连接大脑和周围神经系统的脊髓的病理紊乱起着重要作用，但 ILBD 的病理学尚未得到充分研究。本研究纳入了 18 例 ILBD 病例和 8 例年龄匹配的 LBD 病例。使用抗磷酸化 α-突触核蛋白 (pαSyn) 抗体对 LB 相关病理进行免疫组织化学评估，揭示 15 例 (83.3%) ILBD 病例脊髓中存在 LB 相关病理。通过详细比较颈椎、胸椎、腰椎和骶椎节段，尝试确定脊髓中 pαSyn 沉积的早期模式。大多数 pαSyn 阳性结构分布在脊髓自主神经核内和周围。胸段中间外侧核 (Th/IML) 是受影响最频繁且最严重的区域，表明 Th/IML 是最先受影响的结构。此外，在分析 pαSyn 阳性结构的分布模式后，怀疑 LB 相关病理通过累及脊髓中易受 αSyn 影响的神经元而向尾椎进展。值得注意的是，本研究中纳入的ILBD病例比先前研究中纳入的PD病例处于更早阶段，并且本研究提供了新的、先前未描述的信息。
Incidental Lewy body disease (ILBD) represents the early asymptomatic phase of Lewy body diseases (LBD), including idiopathic Parkinson's disease (PD). Although pathological disturbances in the spinal cord, which connects the brain to the peripheral nervous system, plays an important role, the pathology of ILBD has not been adequately examined. Eighteen ILBD and eight age‐matched LBD cases were enrolled in the present study. LB‐related pathology was immunohistochemically evaluated using anti‐phosphorylated α‐synuclein (pαSyn) antibodies, revealing LB‐related pathology in the spinal cords of 15 (83.3%) of the ILBD cases. Attempts were made to identify the early pattern of pαSyn deposition in the spinal cord by comparing the cervical, thoracic, lumbar and sacral segments in detail. Most pαSyn‐positive structures were distributed in and around the autonomic nuclei of the spinal cord. The intermediolateral nuclei in the thoracic segments (Th/IML) were the most frequently and severely affected region, suggesting that Th/IML are the first structures affected. Furthermore, following analysis of the distribution pattern of the pαSyn‐positive structures, it is suspected that LB‐related pathology progresses toward the caudal vertebrae by involving neurons in the spinal cord that are vulnerable to αSyn. It should be noted that the ILBD cases enrolled in the present study were in an earlier stage than the PD cases enrolled in the previous study, and that the present study provides new, previously undescribed information.
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DOI：
--
发表时间：
2008
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
S. Orimo;T. Uchihara;A. Nakamura;F. Mori;A. Kakita;K. Wakabayashi;H. Takahashi
通讯作者：
S. Orimo;T. Uchihara;A. Nakamura;F. Mori;A. Kakita;K. Wakabayashi;H. Takahashi
DOI：
10.1097/nen.0b013e3180517454
发表时间：
2007-05-01
影响因子：
3.2
作者：
Fumimura, Yuichi;Ikemura, Masako;Murayama, Shigeo
通讯作者：
Murayama, Shigeo
影响因子：
2
作者：
Levens, Alison;Lupton, David W.
通讯作者：
Lupton, David W.
路易体痴呆伴有明显自主神经衰竭和反复心肺骤停的尸检结果。
DOI：
--
发表时间：
2005
期刊：
Rinsho Shinkeigaku 45
影响因子：
--
作者：
Iwasaki Y;Yokokawa Y;Aiba I;Yoshida M.
通讯作者：
Yoshida M.
影响因子：
6.4
作者：
Orimo, Satoshi;Takahashi, Atsushi;Takahashi, Hitoshi
通讯作者：
Takahashi, Hitoshi