Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.
Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.
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DOI：
10.1016/j.ydbio.2021.01.019
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发表时间：
2021-07
影响因子：
2.7
通讯作者：
Reis T
中科院分区：
文献类型：
--
作者：
Gillette CM;Tennessen JM;Reis T
维持生命需要有效地吸收营养并转化为可用的形式。这个过程中几乎所有的东西都是动态的。养分供应波动和不断变化的环境条件提出了新的需求，可以从生物合成和大分子储存到能量消耗的代谢平衡。与此同时，生物体本身也会发生变化，特别是在早期发育的快速生长和分化期间，以及在成年后的生活中。在这里，我们回顾了从果蝇作为实验模型的外部信号，信号通路，组织和器官之间的连接，使动物能够平衡能量储存与支出的变化，内在和外在的。
Sustaining life requires efficient uptake of nutrients and conversion to usable forms. Almost everything about this process is dynamic. Nutrient availability fluctuates and changing environmental conditions impose new demands that can tip the metabolic equilibrium from biosynthesis and macromolecule storage to energy expenditure. At the same time, the organism itself changes, particularly during the rapid growth and differentiation in early development and also later in life as the adult ages. Here we review what has been learned from Drosophila melanogaster as an experimental model about the connections between external signals, signaling pathways, tissues and organs that allow animals to balance energy storage with expenditure in the face of change, both intrinsic and extrinsic.
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影响因子：
2.7
作者：
BRYANT, PJ;LEVINSON, P
通讯作者：
LEVINSON, P
影响因子：
29
作者：
Beshel J;Dubnau J;Zhong Y
通讯作者：
Zhong Y
影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
影响因子：
1.6
作者：
Beadle, GW;Tatum, EL;Clancy, CW
通讯作者：
Clancy, CW
影响因子：
56.9
作者：
Delanoue, Renald;Meschi, Eleonora;Leopold, Pierre
通讯作者：
Leopold, Pierre