A Longitudinal Study of Bone Gain in Pubertal Girls: Anthropometric and Biochemical Correlates
A Longitudinal Study of Bone Gain in Pubertal Girls: Anthropometric and Biochemical Correlates
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青春期女孩骨质增加的纵向研究：人体测量和生化相关性
DOI：
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发表时间：
1998
影响因子：
6.2
通讯作者：
R. Eastell
中科院分区：
文献类型：
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作者：
J. Cadogan;A. Blumsohn;M. Barker;R. Eastell
这项纵向研究的目的是调查青春期女孩骨矿获得的相关因素。受试者为37名健康的高加索女孩，年龄12.1岁(SD 0.3)。在18个月期间每隔6个月进行一次测量，包括双能X线骨密度仪测定全身骨矿含量(TBBMC)、全身骨矿密度(TBBMD)、瘦体重和脂肪质量、人体测量、生活方式因素、骨转换、激素状态和钙吸收分数等四项生化指标。在多元回归分析中，相对增重的相关因素是瘦体重(p<；0.001)和雌二醇(p=0.008)。对于全身性骨密度，相关因素是瘦肉量(p<；0.001)和脂肪质量(p=0.003)、雌二醇(p<；0.001)、膳食能量摄入量(p=0.003)和甲状旁腺激素(p=0.023)。状态生长和骨量增加没有相关性；身高速度和骨转换都在月经初潮前20个月达到∼峰值，而骨量增长在月经初潮时达到峰值。骨转换指标与身高速度相关(0.40<；r<；0.62)，但与骨量无关。雌二醇与骨转换的所有指标均呈独立的负相关(−为0.67；r<；−为0.80)。我们得出的结论是，雌二醇是青春期女孩骨矿物质获得的重要决定因素，可能是青春期后期骨转换减少的原因；瘦质量是与骨获得关系最密切的身体成分参数；身高增长和骨获得在青春期快速生长期间是分离的；骨转换标志物与身高增加有一定的相关性，但不能预测骨获得。
The aim of this longitudinal study was to investigate the factors associated with bone mineral acquisition in pubertal girls. Subjects were 37 healthy, Caucasian girls aged 12.1 years (SD 0.3). Measurements were made at 6‐month intervals over a period of 18 months and included total body bone mineral content (TBBMC), total body bone mineral density (TBBMD), lean mass, and fat mass by dual‐energy X‐ray absorptiometry, anthropometry, lifestyle factors, four biochemical markers of bone turnover, hormonal status, and fractional calcium absorption. In multiple regression analysis, correlates of relative gain in TBBMC were gain in lean mass (p < 0.001) and estradiol (p = 0.008). For TBBMD, correlates were gain in lean (p < 0.001) and fat mass (p = 0.003), estradiol (p < 0.001), dietary energy intake (p = 0.003), and parathyroid hormone (p = 0.023). Statural growth and gain in bone mass were unrelated; both height velocity and bone turnover peaked ∼20 months prior to menarche, whereas gain in bone mass peaked at menarche. Bone turnover markers correlated with height velocity (0.40 < r < 0.62), but not with bone gain. Estradiol was independently and negatively associated with all markers of bone turnover (−0.67 < r < −0.80). We conclude that estradiol is an important determinant of bone mineral gain in pubertal girls and is probably responsible for the reduction in bone turnover in late puberty; lean mass was the body composition parameter most closely associated with bone gain; height gain and bone gain are dissociated during the period of rapid growth at puberty; and bone turnover markers are modestly related to height gain, but are not predictive of bone gain.
影响因子：
15.9
作者：
MATKOVIC, V;JELIC, T;HEANEY, RP
通讯作者：
HEANEY, RP