A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study.
A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study.
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miR-146a 的单核苷酸多态性与银屑病：关联和功能研究
DOI：
10.1111/jcmm.12359
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发表时间：
2014-11
影响因子：
5.3
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zhang W;Yi X;Guo S;Shi Q;Wei C;Li X;Gao L;Wang G;Gao T;Wang L;Li C
表皮生长因子受体（EGFR）在银屑病皮损中过度表达，已被证明有助于银屑病角质形成细胞的过度增殖。参与调节EGFR表达的miRNAs的单核苷酸多态性（SNPs）可能影响银屑病的发生发展。本研究调查了中国汉族人群中miR-146 a中rs 2910164的功能性SNP与银屑病风险之间的关系。本研究共招募了521名汉族银屑病患者和582名健康对照者。通过聚合酶链反应-限制性片段长度多态性对miR-146 a rs 2910164 SNP进行基因分型。总体而言，银屑病风险显著增加与rs 2910164 miR-146 a CG和GG基因型相关（校正OR，1.38; 95% CI，1.06-1.80）。此外，miR-146 a中的rs 2910164 G等位基因减弱了其对表皮生长因子受体（EGFR）表达和角质形成细胞增殖的抑制性调节，降低了银屑病皮损中miR-146 a的水平。这些结果表明，miR-146 a中的rs 2910164 G等位基因可能通过降低对靶基因EGFR的抑制来减弱其对角质形成细胞增殖的抑制，这可能是该研究人群中银屑病风险增加的原因。
Epidermal growth factor receptor (EGFR), which is overexpressed in psoriatic lesions, has been proven to contribute to the hyperproliferation of keratinocytes in psoriasis. Single nucleotide polymorphisms (SNPs) involved in miRNAs that can regulate the expression of EGFR could potentially influence the development of psoriasis. The present study investigated the association between a functional SNP of rs2910164 in miR‐146a and the risk of psoriasis in the Chinese Han population. A total of 521 Han Chinese patients with psoriasis and 582 healthy controls were recruited in this study. The miR‐146a rs2910164 SNP was genotyped by polymerase chain reaction‐restriction fragment length polymorphism. Overall, a significantly increased risk of psoriasis was associated with the rs2910164 miR‐146a CG and GG genotypes (adjusted OR, 1.38; 95% CI, 1.06–1.80). Furthermore, the rs2910164G allele in miR‐146a attenuated its inhibitory regulation on the expression of EGFR as well as the proliferation of human keratinocytes, and lowered the level of miR‐146a in the psoriatic lesions. These findings indicate that the rs2910164G allele in miR‐146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR, which may account for the increased risk of psoriasis in this study population.
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pre-microRNA 基因的遗传多态性作为结直肠癌的预后标志物。
DOI：
10.1158/1055-9965.epi-11-0624
发表时间：
2012-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Xing J;Wan S;Zhou F;Qu F;Li B;Myers RE;Fu X;Palazzo JP;He X;Chen Z;Yang H
通讯作者：
Yang H
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影响因子：
2.5
作者：
Guo, Sen;Zhang, Weigang;Li, Chunying
通讯作者：
Li, Chunying
影响因子：
3.5
作者：
Joyce, Cailin E.;Zhou, Xiang;Bowcock, Anne M.
通讯作者：
Bowcock, Anne M.
DOI：
10.1073/pnas.0802682105
发表时间：
2008-05-20
影响因子：
11.1
作者：
Jazdzewski, Krystian;Murray, Elizabeth L.;de la Chapelle, Albert
通讯作者：
de la Chapelle, Albert
影响因子：
3.5
作者：
Duan, Ranhui;Pak, ChangHui;Jin, Peng
通讯作者：
Jin, Peng