Predictors of neurodevelopmental outcomes in preterm infants with intraparenchymal hemorrhage.
Predictors of neurodevelopmental outcomes in preterm infants with intraparenchymal hemorrhage.
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DOI：
10.1038/jp.2014.21
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发表时间：
2014-05
影响因子：
2.9
通讯作者：
Kennedy, K. A.
中科院分区：
文献类型：
--
作者：
Tsai, A. J.;Lasky, R. E.;John, S. D.;Evans, P. W.;Kennedy, K. A.
确定哪些神经影像学、临床和社会人口学因素可预测脑实质内出血（IPH）极早产儿18-22月龄时的神经发育。对42日龄前进行的头颅超声检查和出院时附近进行的脑部头颅超声/磁共振成像进行了审查，以确定出血位置和其他异常。从现有数据库中提取临床和社会人口学因素。主要结局是脑瘫（CP）的存在，次要结局是认知发育（贝利婴儿发育量表）。在1168名婴儿（<1000 g或<27周）中，141名婴儿患有IPH，48名婴儿在随访中被发现。所有患有广泛性脑叶（涉及三个或更多个脑叶）的婴儿都发生了CP。在早期影像学检查中（42日龄以前），脑室扩大、脑室内出血（IVH）和广泛出血是CP的预测因素。在出院时进行的影像学检查中，脑室扩大、脑室内回声密度和有脑室分流是CP的预测因素。临床、影像学和社会人口学因素与低认知评分无关。在IPH存活的早产儿中，广泛出血，脑室扩大，IVH和分流增加了发展CP的风险。
To determine which neuroimaging, clinical and sociodemographic factors predict neurodevelopment at 18–22 months age among extremely preterm infants with intraparenchymal hemorrhage (IPH). Cranial ultrasounds performed before 42 days of age and cranial ultrasounds/magnetic resonance images of the brain performed near discharge were reviewed for hemorrhage location and other abnormalities. Clinical and sociodemographic factors were extracted from existing databases. The primary outcome was presence of cerebral palsy (CP) and the secondary outcome was cognitive development (Bayley Scales of Infant Development). Of 1168 infants (<1000 g or <27 weeks), 141 infants had an IPH and 48 infants were seen in follow-up. All infants with extensive hemorrhages (involving three or more lobes) developed CP. In early imaging (before 42 days of age), ventriculomegaly, intraventricular hemorrhage (IVH) and extensive hemorrhage were predictors of CP. In imaging performed near discharge, ventriculomegaly, intraventricular echodensity and having a ventricular shunt were predictors of CP. Clinical, imaging and sociodemographic factors were not associated with low cognitive score. In preterm infants surviving with IPH, extensive hemorrhage, ventriculomegaly, IVH and having a shunt increased the risk of developing CP.
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影响因子：
2.9
作者：
Goldstein, R. F.;Cotten, C. M.;Poole, W. K.
通讯作者：
Poole, W. K.
影响因子：
8
作者：
Bassan, Haim;Limperopoulos, Catherine;du Plessis, Adre J.
通讯作者：
du Plessis, Adre J.
影响因子：
5.1
作者：
PAPILE, LA;MUNSICKBRUNO, G;SCHAEFER, A
通讯作者：
SCHAEFER, A
影响因子：
8
作者：
Roze, Elise;Kerstjens, Jorien M.;Bos, Arend F.
通讯作者：
Bos, Arend F.
影响因子：
8
作者：
Luu TM;Ment LR;Schneider KC;Katz KH;Allan WC;Vohr BR
通讯作者：
Vohr BR