Cerebellar volume and cognitive functioning in children who experienced early deprivation.
Cerebellar volume and cognitive functioning in children who experienced early deprivation.
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DOI：
10.1016/j.biopsych.2009.06.014
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发表时间：
2009-12-15
影响因子：
10.6
通讯作者：
Pollak SD
中科院分区：
文献类型：
--
作者：
Bauer PM;Hanson JL;Pierson RK;Davidson RJ;Pollak SD
小脑是主要在运动和相关辅助运动功能的协调中被识别的脑区域。此外，新出现的证据表明小脑参与认知过程，并表明该大脑区域可能会受到经验依赖的结构可塑性变化的影响。因此，本研究的目的是评估早期环境剥夺在小脑成熟和认知发展方面的作用。将31名先前被忽视的儿童和30名发育正常的儿童的12个小脑亚区的结构MRI体积与受试者相应的神经心理测试评分进行比较。忽视儿童小脑上后叶体积较小。此外，上后叶体积被发现调解组之间的神经心理学测试性能差异，与更大的体积产生更好的结果的记忆和规划的测试。这些数据支持小脑结构中经验依赖性可塑性变化的重要性，并突出了小脑在高级认知功能中的作用。
The cerebellum is a brain region recognized primarily in the coordination of movement and related accessory motor functions. In addition, emerging evidence implicates the cerebellum in cognitive processes and suggests that this brain region may be subject to experience-dependent plastic changes in structure. Therefore, the aim of this study was to evaluate the role of early environmental deprivation in the maturation of the cerebellum and aspects of cognitive development. Structural MRI volumes of 12 cerebellar sub-regions from 31 previously-neglected and 30 typically developing children were compared to subjects’ corresponding neuropsychological test scores. Neglected children had smaller volume of the superior-posterior cerebellar lobes. Moreover, superior-posterior lobe volume was found to mediate neuropsychological test performance differences between groups, with larger volumes yielding better outcomes on tests of memory and planning. These data support the importance of experience-dependent plastic changes in cerebellar structure and highlight the role of the cerebellum in higher cognitive functions.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
5.7
作者：
Magnotta, VA;Harris, G;Heckel, D
通讯作者：
Heckel, D
DOI：
10.1111/j.1749-6632.2002.tb07575.x
发表时间：
2002-01-01
期刊：
CREBELLUM: RECENT DEVELOPMENTS IN CEREBELLAR RESEARCH
影响因子：
--
作者：
Dum, RP;Li, C;Strick, PL
通讯作者：
Strick, PL
影响因子：
120.7
作者：
Albers, LH;Johnson, DE;Miller, LC
通讯作者：
Miller, LC
影响因子：
3.6
作者：
Beckett, Celia;Maughan, Barbara;Sonuga-Barke, Edmund J. S.
通讯作者：
Sonuga-Barke, Edmund J. S.