The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses.
The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses.
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抗癌 T 细胞免疫反应中 MHC 呈递的抗原加工中自噬和内/外泌体途径之间的串扰
DOI：
10.1186/s13045-017-0534-8
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发表时间：
2017-10-23
影响因子：
28.5
通讯作者：
Qian W
中科院分区：
文献类型：
--
作者：
You L;Mao L;Wei J;Jin S;Yang C;Liu H;Zhu L;Qian W
T细胞识别以主要组织相容性复合体（MHC）分子多肽形式呈现给它们的蛋白水解产物中的抗原片段，这对于T细胞识别感染或转化的细胞至关重要。自噬是一种为溶酶体降解提供细胞质成分的过程，已被观察到为MHC向T细胞呈递提供细胞内和细胞外抗原的大量来源，这将影响肿瘤特异性免疫反应。同时，细胞外成分通过内/外泌体途径转运到细胞质中进行降解/分泌过程，从而参与多种生理和病理过程，包括免疫反应。自噬和内/外泌体通路以高度复杂的方式交织在一起，两者都密切参与MHC呈递的抗原加工；因此，我们认为它们可能在抗癌T细胞免疫反应中协调抗原加工和递呈。在本文中，我们讨论了自噬和内/外泌体途径之间的分子和功能串扰，以及它们在抗癌T细胞免疫应答中对MHC呈递抗原加工的贡献。
T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cytoplasmic constituents for lysosomal degradation, has been observed to provide a substantial source of intra- and extracellular antigens for MHC presentation to T cells, which will impact the tumor-specific immune response. Meanwhile, extracellular components are transported to cytoplasm for the degradation/secretion process by the endo-/exosomal pathway and are thus involved in multiple physiological and pathological processes, including immune responses. Autophagy and endo-/exosomal pathways are intertwined in a highly intricate manner and both are closely involved in antigen processing for MHC presentation; thus, we propose that they may coordinate in antigen processing and presentation in anticancer T cell immune responses. In this article, we discuss the molecular and functional crosstalk between autophagy and endo-/exosomal pathways and their contributions to antigen processing for MHC presentation in anticancer T cell immune responses.
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DOI：
10.1038/mt.2008.1
发表时间：
2008-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dai S;Wei D;Wu Z;Zhou X;Wei X;Huang H;Li G
通讯作者：
Li G
DOI：
10.1007/s00109-006-0102-0
发表时间：
2006-12
期刊：
Journal of molecular medicine (Berlin, Germany)
影响因子：
--
作者：
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通讯作者：
Cao X
影响因子：
5.5
作者：
André, F;Scharz, NEC;Zitvogel, L
通讯作者：
Zitvogel, L
影响因子：
20.3
作者：
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Anstee, David J.
影响因子：
2.2
作者：
Clayton, A;Court, J;Jasani, B
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Jasani, B