Upregulation of PPARgamma in tissue with gastric carcinoma.
Upregulation of PPARgamma in tissue with gastric carcinoma.
复制标题
胃癌组织中 PPARgamma 的上调。
作者：
我们首次研究了过氧化物酶体增殖物激活受体γ（PPARgamma）在慢性胃炎、胃粘膜异型增生和胃癌中的表达。采用免疫组织化学方法检测53例胃癌、18例胃粘膜不典型增生、30例慢性萎缩性胃炎、31例慢性非萎缩性胃炎组织中PPARgamma的表达。在胃癌、胃粘膜异型增生、慢性萎缩性胃炎和慢性非萎缩性胃炎中，PPARgamma阳性率分别为41.5%、27.8%、10.0%和6.5%。与慢性胃炎相比，胃粘膜异型增生和胃癌组织中PPARgamma的表达明显增强（p < 0.05）。在胃癌中，PPARgamma的表达与肿瘤细胞分化程度和淋巴结转移无关（p > 0.05）。综上所述，PPARgamma的过度表达在人胃癌中是明显的，这可能是癌发生的早期事件。
Here we have for the first time investigated the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in chronic gastritis, gastric mucosal dysplasia, and gastric carcinoma. Avidin-biotin peroxidase complex immunohistochemical methods were adopted to examine the expression of PPARgamma in 53 patients with gastric carcinoma, 18 with gastric mucosal dysplasia, 30 with chronic atrophic gastritis, and 31 with chronic non-atrophic gastritis. The positive rate of PPARgamma was 41.5% in gastric carcinoma, 27.8% in gastric mucosal dysplasia, 10.0% in chronic atrophic gastritis, and 6.5% in chronic non-atrophic gastritis, respectively. Compared with those in chronic gastritis, expression of PPARgamma in gastric mucosal dysplasia and gastric carcinoma was significantly enhanced (p < 0.05). In gastric carcinoma, expression of PPARgamma was not associated with tumor cell differentiation and metastasis to lymph nodes (p > 0.05). Taken together, overexpression of PPARgamma was apparent in human gastric cancer, which might be an early event in carcinogenesis.
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