Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii.
Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii.
复制标题
DOI：
10.1111/j.1365-2036.2009.04102.x
复制
发表时间：
2009-10-15
影响因子：
7.6
通讯作者：
Pothoulakis C
中科院分区：
文献类型：
--
作者：
Pothoulakis C
博拉迪酵母菌（S. bourlardii）是一种研究充分的益生菌，可有效治疗多种病理生理的炎症性胃肠道疾病，如炎症性肠病（IBD）和细菌或肠毒素介导的腹泻和炎症。讨论博氏菌抗炎作用的作用机制，综述该益生菌抗炎作用的相关文献。已经确定了几种针对宿主和致病微生物的作用机制。博氏弧菌和博氏弧菌分泌蛋白（s . bourlardii分泌蛋白）通过干扰炎症核因子κB的全局介质，调节丝裂原活化蛋白激酶ERK1/2和p38的活性，抑制促炎细胞因子的产生。博氏沙门氏菌激活过氧化物酶体增殖物激活受体γ (PPAR-γ)的表达，保护肠道炎症和IBD。博氏梭菌还能抑制“细菌过度生长”和宿主细胞粘附，释放一种蛋白酶，裂解艰难梭菌毒素a及其肠道受体，并刺激针对毒素a的抗体产生。最近的研究结果表明，博氏梭菌可能通过将T细胞困在肠系膜淋巴结中来干扰IBD的发病机制。博氏梭菌发挥的多种抗炎机制为其在肠道炎症状态中的有效性提供了分子解释。
Saccharomyces boulardii (S. boulardii), a well-studied probiotic, can be effective in inflammatory gastrointestinal diseases with diverse pathophysiology, such as Inflammatory Bowel Disease (IBD), and bacterially – or enterotoxin-mediated diarrhea and inflammation. Discuss the mechanisms of action involved in the intestinal anti-inflammatory action of S. boulardii Review of the literature related to the anti-inflammatory effects of this probiotic. Several mechanisms of action have been identified directed against the host and pathogenic microorganisms. S. boulardii and S. boulardii secreted protein(s) inhibit production of proinflammatory cytokines by interfering with the global mediator of inflammation nuclear factor κB, and modulating the activity of the mitogen-activated protein kinases ERK1/2 and p38. S. boulardii activates expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ) that protects from gut inflammation and IBD. S. boulardii also suppresses “bacteria overgrowth” and host cell adherence, releases a protease that cleaves C. difficile toxin A and its intestinal receptor, and stimulates antibody production against toxin A. Recent results indicate that S. boulardii may interfere with IBD pathogenesis by trapping T cells in mesenteric lymph nodes. The multiple anti-inflammatory mechanisms exerted by S. boulardii provide molecular explanations supporting its effectiveness in intestinal inflammatory states.
登录
查看更多内容
影响因子：
3.1
作者：
Castagliuolo, I;Riegler, MF;Pothoulakis, C
通讯作者：
Pothoulakis, C
影响因子：
29.4
作者：
Dalmasso, Guillaume;Cottrez, Francoise;Groux, Herve
通讯作者：
Groux, Herve
影响因子：
3.1
作者：
ECKMANN, L;KAGNOFF, MF;FIERER, J
通讯作者：
FIERER, J
影响因子：
4.4
作者：
Gobert, Alain P.;Vareille, Marjolaine;Martin, Christine
通讯作者：
Martin, Christine
影响因子：
2.9
作者：
Jawhara, Samir;Poulain, Daniel
通讯作者：
Poulain, Daniel