Fasting glucose level and the risk of incident atherosclerotic cardiovascular diseases.
Fasting glucose level and the risk of incident atherosclerotic cardiovascular diseases.
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DOI：
10.2337/dc12-1577
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发表时间：
2013-07
期刊：
影响因子：
16.2
通讯作者：
Samet JM
中科院分区：
文献类型：
--
作者：
Park C;Guallar E;Linton JA;Lee DC;Jang Y;Son DK;Han EJ;Baek SJ;Yun YD;Jee SH;Samet JM
虽然糖尿病增加了心血管疾病（CVD）和死亡的风险，但空腹血糖水平低于糖尿病诊断水平与心血管事件之间的剂量-反应关系尚未得到很好的表征。对超过100万韩国人进行了一项前瞻性队列研究，平均随访16年。共有1，197，384名韩国成年人没有诊断出特定的医疗条件，根据基线空腹血清葡萄糖水平进行分类。采用多因素比例风险回归分析空腹血糖水平与CVD发病率和死亡率、卒中发病率和死亡率以及全因死亡率的关系。空腹血糖水平与心血管疾病风险之间的关系通常遵循J形曲线，在85-99 mg/dL的血糖范围内风险最低。当空腹血糖水平增加到>100 mg/dL时，CVD、缺血性心脏病、心肌梗死和血栓性卒中的风险逐渐增加，但出血性卒中的风险没有增加。空腹血糖水平<70 mg/dL与男性所有卒中风险增加（风险比1.06，95% CI 1.01-1.11）和女性所有卒中风险增加（风险比1.11，1.05-1.17）相关。低血糖水平和空腹血糖受损应被视为脑卒中和冠心病风险的预测因子。与最低心血管风险相关的空腹血糖水平可能在一个狭窄的范围内。
Although diabetes increases the risk of cardiovascular disease (CVD) and mortality, the dose-response relationship between fasting glucose levels below those diagnostic of diabetes with cardiovascular events has not been well characterized. A prospective cohort study of more than one million Koreans was conducted with a mean follow-up of 16 years. A total of 1,197,384 Korean adults with no specific medical conditions diagnosed were classified by baseline fasting serum glucose level. Associations of fasting glucose level with CVD incidence and mortality, stroke incidence and mortality, and all-cause mortality were analyzed using multivariate proportional hazards regression. The relationships between fasting glucose levels and CVD risks generally followed J-shape curves, with lowest risk in the glucose range of 85–99 mg/dL. As fasting glucose levels increased to >100 mg/dL, risks for CVD, ischemic heart disease, myocardial infarction, and thrombotic stroke progressively increased, but risk for hemorrhagic stroke did not. Fasting glucose levels <70 mg/dL were associated with increased risk of all stroke (hazard ratio 1.06, 95% CI 1.01–1.11) in men and (hazard ratio 1.11, 1.05–1.17) in women. Both low glucose level and impaired fasting glucose should be considered as predictors of risk for stroke and coronary heart disease. The fasting glucose level associated with the lowest cardiovascular risk may be in a narrow range.
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影响因子：
16.2
作者：
Pankow, James S.;Kwan, David K.;Ballantyne, Christie M.
通讯作者：
Ballantyne, Christie M.
影响因子：
8.3
作者：
Tanne, D;Koren-Morag, N;Goldbourt, U
通讯作者：
Goldbourt, U
DOI：
10.1056/nejmoa0908359
发表时间：
2010-03-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Selvin E;Steffes MW;Zhu H;Matsushita K;Wagenknecht L;Pankow J;Coresh J;Brancati FL
通讯作者：
Brancati FL
影响因子：
16.2
作者：
Balkau, B;Bertrais, S;Eschwege, E
通讯作者：
Eschwege, E
影响因子：
2.9
作者：
Kimm H;Yun JE;Lee SH;Jang Y;Jee SH
通讯作者：
Jee SH