Processing of food, body and emotional stimuli in anorexia nervosa: a systematic review and meta-analysis of functional magnetic resonance imaging studies.

Processing of food, body and emotional stimuli in anorexia nervosa: a systematic review and meta-analysis of functional magnetic resonance imaging studies.
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神经性厌食症的食物、身体和情绪刺激的处理:功能磁共振成像研究的系统回顾和荟萃分析。

DOI:
10.1002/erv.2197
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发表时间:
2012
期刊:
European eating disorders review : the journal of the Eating Disorders Association
影响因子:
--
通讯作者:
P. Enck
P. Enck
中科院分区:
--
文献类型:
--
作者:
Yikang Zhu;Xiaochen Hu;Jijun Wang;Jue Chen;Qian Guo;Chunbo Li;P. Enck

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神经性厌食症(AN)患者对食物、身体和情绪信息的认知加工特点存在争议。我们回顾了功能磁共振成像研究,以评估迄今为止的研究中是否有一致的神经基础和网络。检索PubMed、奥维德、Web of Science、科克伦图书馆和谷歌学术1980年1月至2012年5月,我们确定了17项相关研究。激活似然估计被用来执行功能磁共振成像研究的定量荟萃分析。对于食物刺激和身体刺激,AN患者表现出增加的血流动力学反应的情绪相关区域(额叶,尾状核,钩,颞叶和颞叶)和减少激活顶叶区域。虽然没有强大的大脑激活已被发现在响应情绪刺激,情绪相关的神经网络参与处理的食物和身体刺激之间的AN。提示AN患者的负性情绪唤起与对食物和身体刺激的认知加工偏差有关。
The characteristics of the cognitive processing of food, body and emotional information in patients with anorexia nervosa (AN) are debatable. We reviewed functional magnetic resonance imaging studies to assess whether there were consistent neural basis and networks in the studies to date. Searching PubMed, Ovid, Web of Science, The Cochrane Library and Google Scholar between January 1980 and May 2012, we identified 17 relevant studies. Activation likelihood estimation was used to perform a quantitative meta-analysis of functional magnetic resonance imaging studies. For both food stimuli and body stimuli, AN patients showed increased hemodynamic response in the emotion-related regions (frontal, caudate, uncus, insula and temporal) and decreased activation in the parietal region. Although no robust brain activation has been found in response to emotional stimuli, emotion-related neural networks are involved in the processing of food and body stimuli among AN. It suggests that negative emotional arousal is related to cognitive processing bias of food and body stimuli in AN.
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