Response properties of MST parafoveal neurons during smooth pursuit adaptation.

Response properties of MST parafoveal neurons during smooth pursuit adaptation.
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MST 中心凹旁神经元在平滑追踪适应过程中的响应特性。

DOI:
10.1152/jn.00203.2016
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发表时间:
2016
影响因子:
2.5
通讯作者:
Mustari,MichaelJ
Mustari,MichaelJ
中科院分区:
医学3区
文献类型:
--
作者:
Ono,Seiji;Mustari,MichaelJ

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后顶叶皮质中的视觉运动神经元在引导平滑的眼球追动运动中发挥着关键作用。初始追踪(开环期)部分是由来自皮质区域(例如内侧上颞区(MST))的视觉运动信号驱动的。本研究的目的是确定初始追踪增益的适应是否是由于皮质水平神经元视觉敏感性的改变而产生的。众所周知,MST中的视觉运动反应在受到大视场视觉运动刺激后受到抑制,表现出视觉运动适应。一种假设是 MST 中的中心凹运动反应与使用小目标点的平滑追踪适应相关。我们使用了具有两步目标速度的步进斜坡跟踪任务(双步范式),这会引起增益下降或增益适应。我们发现,在增益下降适应后,58% 的 MST 视觉神经元的放电率显着下降。即使来自目标运动的视觉运动输入(在追踪开始之前)是恒定的,情况也是如此。因此,增益下降范式期间的重复视觉刺激可能导致视觉反应的适应性变化。然而,适应的时间过程并没有显示出视觉反应和追逐行为之间的相关性。这些结果表明,MST 中的视觉反应可能不会直接影响追击发起的适应性变化。
Visual motion neurons in the posterior parietal cortex play a critical role in the guidance of smooth pursuit eye movements. Initial pursuit (open-loop period) is driven, in part, by visual motion signals from cortical areas, such as the medial superior temporal area (MST). The purpose of this study was to determine whether adaptation of initial pursuit gain arises because of altered visual sensitivity of neurons at the cortical level. It is well known that the visual motion response in MST is suppressed after exposure to a large-field visual motion stimulus, showing visual motion adaptation. One hypothesis is that foveal motion responses in MST are associated with smooth pursuit adaptation using a small target spot. We used a step-ramp tracking task with two steps of target velocity (double-step paradigm), which induces gain-down or gain-up adaptation. We found that after gain-down adaptation 58% of our MST visual neurons showed a significant decrease in firing rate. This was the case even though visual motion input (before the pursuit onset) from target motion was constant. Therefore, repetitive visual stimulation during the gain-down paradigm could lead to adaptive changes in the visual response. However, the time course of adaptation did not show a correlation between the visual response and pursuit behavior. These results indicate that the visual response in MST may not directly contribute to the adaptive change in pursuit initiation.
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