"Awake" intraoperative functional MRI (ai-fMRI) for mapping the eloquent cortex: Is it possible in awake craniotomy?
"Awake" intraoperative functional MRI (ai-fMRI) for mapping the eloquent cortex: Is it possible in awake craniotomy?
复制标题
“清醒”的术中功能性MRI（AI-FMRI）用于绘制雄辩的皮质：在醒着的开裂术中是否有可能？
DOI：
10.1016/j.nicl.2012.12.002
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发表时间：
2012
影响因子：
4.2
通讯作者：
Zhou, Liang-Fu
中科院分区：
文献类型：
--
作者：
Lu, Jun-Feng;Zhang, Han;Wu, Jin-Song;Yao, Cheng-Jun;Zhuang, Dong-Xiao;Qiu, Tian-Ming;Jia, Wen-Bin;Mao, Ying;Zhou, Liang-Fu
关键词：
As a promising noninvasive imaging technique, functional MRI (fMRI) has been extensively adopted as a functional localization procedure for surgical planning. However, the information provided by preoperative fMRI (pre-fMRI) is hampered by the brain deformation that is secondary to surgical procedures. Therefore, intraoperative fMRI (i-fMRI) becomes a potential alternative that can compensate for brain shifts by updating the functional localization information during craniotomy. However, previous i-fMRI studies required that patients be under general anesthesia, preventing the wider application of such a technique as the patients cannot perform tasks unless they are awake. In this study, we propose a new technique that combines awake surgery and i-fMRI, named “awake” i-fMRI (ai-fMRI). We introduced ai-fMRI to the real-time localization of sensorimotor areas during awake craniotomy in seven patients. The results showed that ai-fMRI could successfully detect activations in the bilateral primary sensorimotor areas and supplementary motor areas for all patients, indicating the feasibility of this technique in eloquent area localization. The reliability of ai-fMRI was further validated using intraoperative stimulation mapping (ISM) in two of the seven patients. Comparisons between the pre-fMRI-derived localization result and the ai-fMRI derived result showed that the former was subject to a heavy brain shift and led to incorrect localization, while the latter solved that problem. Additionally, the approaches for the acquisition and processing of the ai-fMRI data were fully illustrated and described. Some practical issues on employing ai-fMRI in awake craniotomy were systemically discussed, and guidelines were provided. ► The concept of awake intraoperative fMRI (ai-fMRI) was first proposed. ► ai-fMRI is feasible and applicable to detect real-time eloquent areas. ► ai-fMRI is reliable in mapping the sensorimotor cortex. ► The pipeline of ai-fMRI mapping is systematically demonstrated. ► The utilization of ai-fMRI extends the application of fMRI and iMRI.
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影响因子：
10.6
作者：
Maurer, CR;Hill, DLG;Truwit, CL
通讯作者：
Truwit, CL
影响因子：
3.6
作者：
Bonhomme, Vincent;Franssen, Collette;Hans, Pol
通讯作者：
Hans, Pol
影响因子：
4.8
作者：
Nimsky, C;Fujita, A;Fahlbusch, R
通讯作者：
Fahlbusch, R
影响因子：
4.8
作者：
Kuhnt, Daniela;Ganslandt, Oliver;Nimsky, Christopher
通讯作者：
Nimsky, Christopher
DOI：
10.1097/rmr.0b013e3181963b46
发表时间：
2009-01-01
期刊：
Topics in magnetic resonance imaging : TMRI
影响因子：
--
作者：
Nabavi, Arya;Goebel, Simone;Mehdorn, Maximilian
通讯作者：
Mehdorn, Maximilian