Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline.
Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline.
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DOI：
10.1016/j.nlm.2010.04.001
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发表时间：
2010-07
影响因子：
2.7
通讯作者：
Bilbo, Staci D.
中科院分区：
文献类型：
--
作者：
Bilbo, Staci D.
关键词：
有显着的个体差异，在老化过程中的认知能力下降，这表明存在“脆弱性因素”的最终赤字。神经炎症可能是一个这样的因素;增加的神经胶质反应性是衰老的常见结果，这反过来又与许多神经退行性疾病有关。早期感染会导致认知障碍，并伴随着年轻人的炎症挑战，这促使我们探索它是否也会加速与衰老相关的认知能力下降。在出生后第4天用PBS或E. coli，分别在2月龄和16月龄时进行学习记忆测试，测试方法包括两个恐惧条件化任务（情境预暴露和模糊线索）和一个空间水迷宫任务。新生感染的大鼠在模糊线索恐惧条件化任务和水迷宫中都表现出记忆障碍，但仅在16个月时。两组之间的焦虑没有差异。与对照组相比，新生感染大鼠的胶质细胞标记物（小胶质细胞上的CD 11b和MHC II，星形胶质细胞上的GFAP）也表现出更大的衰老诱导的增加，以及海马内NMDA受体亚单位表达的选择性变化，但杏仁核或顶叶皮质中没有。总之，这些数据表明，早期感染导致认知老化不太成功，这可能与神经胶质反应性的变化有关。
There is significant individual variability in cognitive decline during aging, suggesting the existence of “vulnerability factors” for eventual deficits. Neuroinflammation may be one such factor; increased glial reactivity is a common outcome of aging, which in turn is associated with numerous neurodegenerative conditions. Early-life infection leads to cognitive impairment in conjunction with an inflammatory challenge in young adulthood, which led us to explore whether it might also accelerate the cognitive decline associated with aging. Rats were treated on postnatal day 4 with PBS or E. coli, and then tested for learning & memory at 2 or 16 month of age, using 2 fear conditioning tasks (context pre-exposure and ambiguous cue), and a spatial water maze task. Neonatally-infected rats exhibited memory impairments in both the ambiguous cue fear-conditioning task and in the water maze, but only at 16 month. There were no differences in anxiety between groups. Neonatally-infected rats also exhibited greater aging-induced increases in glial markers (CD11b and MHC II on microglia, and GFAP on astrocytes), as well as selective changes in NMDA receptor subunit expression within the hippocampus, but not in amygdala or parietal cortex compared to controls. Taken together, these data suggest that early-life infection leads to less successful cognitive aging, which may be linked to changes in glial reactivity.
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影响因子：
2.7
作者：
Bilbo, SD;Rudy, JW;Maier, SF
通讯作者：
Maier, SF
影响因子：
15.1
作者：
Bland, Sondra T.;Beckley, Jacob T.;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
影响因子：
5.3
作者：
Bilbo, SD;Biedenkapp, JC;Maier, SF
通讯作者：
Maier, SF
影响因子：
4
作者：
Nieves-Martinez, E.;Sonntag, W. E.;Nicolle, M. M.
通讯作者：
Nicolle, M. M.
影响因子：
3.9
作者：
Rech, Rafael Luiz;Martins de Lima, Maria Noemia;Schroeder, Nadja
通讯作者：
Schroeder, Nadja