Investigating the early-life determinants of illness in Africa: the Drakenstein Child Health Study.
Investigating the early-life determinants of illness in Africa: the Drakenstein Child Health Study.
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调查非洲疾病的早期决定因素：Drakenstein儿童健康研究。
DOI：
10.1136/thoraxjnl-2014-206242
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发表时间：
2015-06
期刊：
影响因子：
10
通讯作者：
Nicol MP
中科院分区：
文献类型：
--
作者：
Zar HJ;Barnett W;Myer L;Stein DJ;Nicol MP
呼吸系统疾病是全球儿童疾病的主要原因。我们描述了一个独特的多学科南非出生队列，德拉肯斯坦儿童健康研究（DCHS），以调查早期下呼吸道感染（LRTI）对儿童健康的发病率、危险因素、病因和长期影响。来自传染病和环境风险因素高度暴露的贫穷城郊社区的孕妇被纳入1000对母子，随访至少5年。纵向测量生物医学、环境、社会心理和人口风险因素。环境暴露是通过放置在家访中的监测器来测量的。在6周、每年和LRTI发作期间测量儿童的肺功能。微生物学调查包括微生物组和多重PCR测量是纵向和在LRTI发作时进行的。DCHS是一项独特的非洲出生队列研究，使用复杂的措施全面调查世界贫困地区儿童健康的早期决定因素。
Respiratory disease is the predominant cause of illness in children globally. We describe a unique multidisciplinary South African birth cohort, the Drakenstein Child Health Study (DCHS), to investigate the incidence, risk factors, aetiology and long-term impact of early lower respiratory tract infection (LRTI) on child health. Pregnant women from a poor, peri-urban community with high exposure to infectious diseases and environmental risk factors are enrolled with 1000 mother–child pairs followed for at least 5 years. Biomedical, environmental, psychosocial and demographic risk factors are longitudinally measured. Environmental exposures are measured using monitors placed at home visits. Lung function is measured in children at 6 weeks, annually and during LRTI episodes. Microbiological investigations including microbiome and multiplex PCR measures are done longitudinally and at LRTI episodes. The DCHS is a unique African birth cohort study that uses sophisticated measures to comprehensively investigate the early-life determinants of child health in an impoverished area of the world.
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影响因子：
10
作者：
Zar HJ;Madhi SA;Aston SJ;Gordon SB
通讯作者：
Gordon SB
影响因子：
3.7
作者：
Edmond K;Scott S;Korczak V;Ward C;Sanderson C;Theodoratou E;Clark A;Griffiths U;Rudan I;Campbell H
通讯作者：
Campbell H
影响因子：
7.2
作者：
Rudan I;O'Brien KL;Nair H;Liu L;Theodoratou E;Qazi S;Lukšić I;Fischer Walker CL;Black RE;Campbell H;Child Health Epidemiology Reference Group (CHERG)
通讯作者：
Child Health Epidemiology Reference Group (CHERG)
影响因子：
158.5
作者：
Sears, MR;Greene, JM;Poulton, R
通讯作者：
Poulton, R