The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis.
The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis.
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多形性腺瘤基因样2在胃肠道癌症发生、进展和预后中的作用。
DOI：
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Wang, Zhen-Ning
中科院分区：
文献类型：
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作者：
Wang, Mei-Xian;Dong, Yu-Lan;Xu, Hui-Mian;Wang, Zhen-Ning
先前的大量研究表明，多形性腺瘤基因样 2 (PLAGL2) 是一种在癌症进展中活跃的转录因子。本研究的目的是探讨PLAGL2在胃肠道癌发生、进展和预后中的作用。免疫组织化学分析显示PLAGL2在胃肠道肿瘤和邻近正常组织中表达。 PLAGL2在225例结直肠癌组织中的表达显着高于66例癌旁非肿瘤组织（P=0.037）。然而，286 个胃肿瘤和 57 个邻近非肿瘤组织之间的表达没有显着差异（P = 0.352）。此外，结直肠癌中PLAGL2的表达水平与肿瘤浸润深度显着相关（P = 0.030）。然而，PLAGL2 表达水平与胃癌肿瘤大小显着相关（P = 0.046）。此外，我们进行了生存分析，发现较高或较低的 PLAGL2 表达都不是胃肠癌的预后因素。我们的研究结果表明，PALGL2 在结直肠癌的发生和进展中充当肿瘤癌蛋白。然而，该蛋白在胃癌发生、进展和预后中的作用尚不确定。有必要进一步研究 PLAGL2 活性在胃肠道癌症中的分子机制。
Numerous previous studies have revealed that pleomorphic adenoma gene-like 2 (PLAGL2) is a transcription factor that is active in cancer progression. The aim of this study was to investigate the role of PLAGL2 in the development, progression and prognosis of gastrointestinal cancer. Immunohistochemical analysis revealed that PLAGL2 was expressed in gastrointestinal tumors and adjacent normal tissues. The expression of PLAGL2 was significantly higher in 225 colorectal cancer tissues than in 66 adjacent non-tumor tissues (P = 0.037). However, expression was not significantly different between 286 gastric tumors and 57 adjacent non-tumor tissues (P = 0.352). Moreover, the PLAGL2 expression level significantly correlated with the depth of tumor invasion in colorectal cancer (P = 0.030). However, the PLAGL2 expression level significantly correlated with tumor size in gastric cancer (P = 0.046). Furthermore, we performed survival analyses and found that neither higher nor lower PLAGL2 expression was a prognostic factor in gastrointestinal cancer. Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer. However, the role of this protein in the development, progression and prognosis of gastric cancer is uncertain. Further investigation into the molecular mechanisms of PLAGL2 activity in gastrointestinal cancer is warranted.
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影响因子：
11.4
作者：
Landrette, S. F.;Madera, D.;He, F.;Castilla, L. H.
通讯作者：
Castilla, L. H.
影响因子：
7.2
作者：
Hanks, Tracey S.;Gauss, Katherine A.
通讯作者：
Gauss, Katherine A.
DOI：
10.1152/ajplung.00144.2009
发表时间：
2009-07
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
--
作者：
Yih-Sheng Yang;Meng-Chun W. Yang;Yuhong Guo;O. W. Williams;J. Weissler
通讯作者：
Yih-Sheng Yang;Meng-Chun W. Yang;Yuhong Guo;O. W. Williams;J. Weissler
影响因子：
50.3
作者：
H. Kornblum
通讯作者：
H. Kornblum
影响因子：
8
作者：
Furukawa, T;Adachi, Y;Taketani, S
通讯作者：
Taketani, S