Physical approaches for nucleic acid delivery to liver.
Physical approaches for nucleic acid delivery to liver.
复制标题
DOI：
10.1208/s12248-008-9067-y
复制
发表时间：
2008-12
期刊：
影响因子：
4.5
通讯作者：
Liu, Dexi
中科院分区：
文献类型：
--
作者：
Kamimura, Kenya;Liu, Dexi
肝脏是多种代谢途径的关键器官，涉及许多遗传性疾病，尽管这些疾病的病理学不同，但通常是由病变细胞中关键基因产物的缺乏或过度产生引起的。原则上，解决这种问题的直接方法是向这些细胞中引入基因编码序列以提供缺失的基因产物，或引入核酸序列以抑制过量基因产物的产生。然而，实际上，基于核酸的药物的成功取决于能够将DNA或RNA形式的核酸序列递送至肝细胞的方法的可用性。本文综述了近年来核酸在肝脏中的物理传递方法。重点放在迄今为止开发的每种方法的作用机制、优点和缺点上。我们希望所提供的信息将鼓励新的奋进，以改善目前的方法或开发新的战略，这将导致安全和有效的核酸输送到肝脏。
Liver is a key organ for numerous metabolic pathways and involves many inherited diseases that, although being different in their pathology, are often caused by lack or overproduction of a critical gene product in the diseased cells. In principle, a straightforward method to fix such problem is to introduce into these cells with a gene-coding sequence to provide the missing gene product, or with the nucleic acid sequence to inhibit production of the excessive gene product. Practically, however, success of nucleic acid-based pharmaceutics is dependent on availability of a method capable of delivering nucleic acid sequence in the form of DNA or RNA to liver cells. In this review, we will summarize the progress toward development of physical methods for nucleic acid delivery to liver. Emphasis is placed on the mechanism of action, pros and cons of each method developed so far. We hope the information provided will encourage new endeavor to improve the current methodologies or develop new strategies that will lead to safe and effective delivery of nucleic acids to liver.
登录
查看更多内容
影响因子：
5.5
作者：
Drape, Robert J.;Macklin, Michael D.;Dean, Hansi J.
通讯作者：
Dean, Hansi J.
影响因子：
2.9
作者：
Huber, PE;Jenne, J;Pfisterer, P
通讯作者：
Pfisterer, P
影响因子：
4.2
作者：
Jaichandran, S;Yap, STB;Kon, OL
通讯作者：
Kon, OL
影响因子：
4.2
作者：
Arad, U;Zeira, E;Oppenheim, A
通讯作者：
Oppenheim, A
影响因子：
2.9
作者：
Bao, SP;Thrall, BD;Miller, DL
通讯作者：
Miller, DL