De novo electrocardiographic abnormalities in persons living with HIV.
De novo electrocardiographic abnormalities in persons living with HIV.
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DOI：
10.1038/s41598-021-00290-x
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发表时间：
2021-10-21
影响因子：
4.6
通讯作者：
Nielsen SD
中科院分区：
文献类型：
--
作者：
Knudsen AD;Graff C;Nielsen JB;Thomsen MT;Høgh J;Benfield T;Gerstoft J;Køber L;Kofoed KF;Nielsen SD
艾滋病毒感染者（PLWH）可能比未感染者心血管事件的发生率增加，QTc间期延长。我们的目的是研究治疗良好的PLWH中新发主要心电图（ECG）异常和QTc延长的发生率和风险因素。我们纳入了无主要心电图异常的病毒学抑制的PLWH，他们参加了哥本哈根艾滋病感染（COCOMO）研究的2年随访。根据Minnesota Code Manual对ECG进行分类。我们将新发重大ECG异常定义为新的重大明尼苏达代码手册异常。QTc延长定义为女性QTc > 460 ms，男性QTc > 450 ms。在基线时无重大ECG异常的667例PLWH中，34例（5%）在中位2.3年后新发重大ECG异常。调整后，年龄（RR：每10岁1.57 [1.08-2.28]），体重不足（RR：5.79 [1.70-19.71]），目前吸烟（RR：2.34 [1.06-5.16]）、糖尿病（RR：3.89 [1.72-8.80]）和蛋白酶抑制剂使用（RR：2.45 [1.27-4.74）与新发主要ECG异常的风险较高相关。在基线时没有QTc延长的PLWH中，仅11例（1.6%）受试者发生了新发QTc延长。5%治疗良好的PLWH获得性新发主要心电图异常和蛋白酶抑制剂的使用与新发主要心电图异常风险的两倍以上相关。原发性QTc延长很少见，对于治疗良好的PLWH来说似乎不构成问题。
Persons living with HIV (PLWH) may have increased incidence of cardiovascular events and longer QTc intervals than uninfected persons. We aimed to investigate the incidence and risk factors of de novo major electrocardiogram (ECG) abnormalities and QTc prolongation in well-treated PLWH. We included virologically suppressed PLWH without major ECG abnormalities, who attended the 2-year follow-up in the Copenhagen comorbidity in HIV infection (COCOMO) study. ECGs were categorized according to Minnesota Code Manual. We defined de novo major ECG abnormalities as new major Minnesota Code Manual abnormalities. Prolonged QTc was defined as QTc > 460 ms in females and QTc > 450 ms in males. Of 667 PLWH without major ECG abnormalities at baseline, 34 (5%) developed de novo major ECG abnormalities after a median of 2.3 years. After adjustment, age (RR: 1.57 [1.08–2.28] per decade older), being underweight (RR: 5.79 [1.70–19.71]), current smoking (RR: 2.34 [1.06–5.16]), diabetes (RR: 3.89 [1.72–8.80]) and protease inhibitor use (RR: 2.45 [1.27–4.74) were associated with higher risk of getting de novo major ECG abnormalities. Of PLWH without prolonged QTc at baseline, only 11 (1.6%) participants developed de novo prolonged QTc. Five percent of well-treated PLWH acquired de novo major ECG abnormalities and protease inhibitor use was associated with more than twice the risk of de novo major ECG abnormalities. De novo prolonged QTc was rare and did not seem to constitute a problem in well-treated PLWH.
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影响因子：
3.7
作者：
Ronit, Andreas;Haissman, Judith;Nielsen, Susanne Dam
通讯作者：
Nielsen, Susanne Dam
影响因子：
2.7
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Abdelhady, Ahmed M.;Shugg, Tyler;Overholser, Brian R.
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影响因子：
158.5
作者：
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通讯作者：
Lundgren, Jens D.
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28.2
作者：
Chinello, Pierangelo;Lisena, Francesco P.;Petrosillo, Nicola
通讯作者：
Petrosillo, Nicola
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120.7
作者：
Flegal, KM;Graubard, BI;Gail, MH
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Gail, MH