Transcriptional regulation of memory B cell differentiation.
Transcriptional regulation of memory B cell differentiation.
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DOI：
10.1038/s41577-020-00446-2
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Cyster JG
中科院分区：
文献类型：
--
作者：
Laidlaw BJ;Cyster JG
记忆B细胞（MBC）对于再感染后保护性免疫的快速发展至关重要。已经在人类中鉴定出能够中和不同的病原体亚类（例如流感和HIV）的MBC。然而，努力开发疫苗，诱导广泛的保护MBC快速突变的病原体尚未成功。更好地了解调节MBC发育和功能的信号对于克服当前阻碍成功疫苗开发的挑战至关重要。在这里，我们讨论了最近的进展有关的信号和转录因子调控生发中心衍生的MBC的发展和功能。记忆B细胞对于感染或接种疫苗后保护性免疫的形成至关重要，更好地了解这些细胞可以为克服有效疫苗开发中的障碍提供策略。本文综述了调控生发中心来源的记忆B细胞发育和功能的信号和转录因子。
Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been successful. Better understanding of the signals regulating MBC development and function are essential to overcome current challenges hindering successful vaccine development. Here, we discuss recent advancements regarding the signals and transcription factors regulating germinal centre-derived MBC development and function. Memory B cells are critically important for the formation of protective immunity following infection or vaccination, and a better understanding of these cells may inform strategies to overcome hurdles in the development of effective vaccines. This Review discusses the signals and transcription factors that regulate the development and function of germinal centre-derived memory B cells.
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50.3
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