The association between maternal and paternal race and preterm birth.
The association between maternal and paternal race and preterm birth.
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DOI：
10.1016/j.ajogmf.2021.100353
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发表时间：
2021-07
影响因子：
6.3
通讯作者：
Manuck TA
中科院分区：
文献类型：
--
作者：
Green CA;Johnson JD;Vladutiu CJ;Manuck TA
非西班牙裔黑人母亲种族是早产的已知风险因素。然而，父系种族的贡献并没有得到很好的证实。我们试图评估非西班牙裔黑人、非西班牙裔白人以及非西班牙裔黑人和非西班牙裔白人混合双胞胎早产的风险。这是一项基于人口的队列研究，使用了国家生命统计系统的活产记录，对2015至2017年间美国所有的活产婴儿进行了研究。出生记录包括母亲和父亲自我报告的非西班牙裔白人或非西班牙裔黑人的单身、非异常婴儿。主要结果是妊娠37周时的早产；次要结果包括妊娠34周和28周时的早产和分娩孕周(作为连续变量)。数据分析采用卡方检验、t检验、方差分析和Logistic回归分析。并绘制了Kaplan-Meier生存曲线。在研究期间，有11,809,599名活产婴儿；4,008,622名新生儿符合纳入标准。在纳入的新生儿中，291,647人(7.3%)发生在妊娠37周。按照母系种族先于父系种族的惯例，在怀孕37周时早产在非西班牙裔黑人和非西班牙裔黑人中最常见(n=70,987[10.8%])，其次是非西班牙裔黑人和非西班牙裔白人(n=3137[9.5%])，非西班牙裔白人和非西班牙裔黑人(n=9136[8.3%])，以及非西班牙裔白人和非西班牙裔白人二元组(n=209,387[6.5%]；P<；.001为趋势)。在非西班牙裔黑人和非西班牙裔黑人夫妇中，妊娠34周(n=74,474)和28周(n=18,474)出生的婴儿也更常见。具体来说，24,351名(3.7%)非西班牙裔黑人和非西班牙裔黑人，1017名(3.1%)非西班牙裔黑人和非西班牙裔白人，2408名(2.2%)非西班牙裔白人和非西班牙裔黑人，以及46,698名非西班牙裔白人和非西班牙裔白人在<分娩；在妊娠34周时，有7988名非西班牙裔黑人和非西班牙裔黑人(1.2%)，313名(1.0%)非西班牙裔黑人和非西班牙裔白人，584名(0.5%)非西班牙裔白人和非西班牙裔黑人，以及9589名(0.3%)非西班牙裔白人和非西班牙裔白人在妊娠28周时出生。非西班牙裔白人和非西班牙裔白人二联体的平均孕周标准差为38.8±1.7周，而非西班牙裔白人和非西班牙裔黑人、非西班牙裔黑人和非西班牙裔白人以及非西班牙裔黑人和非西班牙裔黑人二联体的孕期分别为38.6±2.0、38.5±2.3和38.3±2.4周(P<；.001)。母亲或父亲种族与早产之间的关联的调整后的优势比在每个孕龄截止时对于非西班牙裔黑人和非西班牙裔黑人二元组最高：调整后的优势比为1.60(95%可信区间，1.11-1.19)(<；37周)；调整后的优势比，2.47(95%可信区间，2.41-2.53)(<；34周)；以及调整后的优势比，4.22(95%可信区间，4.04-4.41)(<；妊娠28周)与非西班牙裔白人参照组进行比较。根据保险状况、慢性高血压、怀孕期间吸烟、先前早产史和男性胎儿进行调整的模型。在Kaplan-Meier生存分析中，与所有其他双胎组合相比，非西班牙裔黑人和非西班牙裔黑人双胎在分娩孕龄范围内分娩得最早。非西班牙裔黑人父系种族是早产的危险因素，在评估母亲先验的早产风险时应予以考虑。未来的研究应该调查这一发现背后的机制，包括确定种族主义、母系和父系遗传学以及表观遗传学等因素对个体早产风险的影响。
Non-Hispanic black maternal race is a known risk factor for preterm birth. However, the contribution of paternal race is not as well established. We sought to evaluate the risk of preterm birth among non-Hispanic black, non-Hispanic white, and mixed non-Hispanic black and non-Hispanic white dyads. This was a population-based cohort study of all live births in the United States from 2015 to 2017, using live birth records from the National Vital Statistics System. Singleton, nonanomalous infants whose live birth record included maternal and paternal self-reported race as either non-Hispanic white or non-Hispanic black were included. The primary outcome was preterm birth at <37 weeks’ gestation; secondary outcomes included preterm birth at <34 and <28 weeks’ gestation and delivery gestational age (as a continuous variable). Data were analyzed using chi-square, t test, analysis of variance, and logistic regression. A Kaplan-Meier survival curve was also generated. There were 11,809,599 live births during the study period; 4,008,622 births met the inclusion criteria. Of included births, 291,647 (7.3%) occurred at <37 weeks’ gestation. Using the convention of maternal race first followed by paternal race, preterm birth at <37 weeks’ gestation was most common among non-Hispanic black and non-Hispanic black dyads (n=70,987 [10.8%]), followed by non-Hispanic black and non-Hispanic white (n=3137 [9.5%]), non-Hispanic white and non-Hispanic black (n=9136 [8.3%]), and non-Hispanic white and non-Hispanic white dyads (n=209,387 [6.5%]; P<.001 for trend). Births at <34 weeks’ (n=74,474) and <28 weeks’ gestation (n=18,474) were also more common among non-Hispanic black and non-Hispanic black dyads. Specifically, 24,351 (3.7%) non-Hispanic black and non-Hispanic black, 1017 (3.1%) non-Hispanic black and non-Hispanic white, 2408 (2.2%) non-Hispanic white and non-Hispanic black, and 46,698 non-Hispanic white and non-Hispanic white dyads delivered at <34 weeks’ gestation, and 7988 non-Hispanic black and non-Hispanic black (1.2%), 313 (1.0%) non-Hispanic black and non-Hispanic white, 584 (0.5%) non-Hispanic white and non-Hispanic black, and 9589 (0.3%) non-Hispanic white and non-Hispanic white dyads delivered at <28 weeks’ gestation. Non-Hispanic white and non-Hispanic white dyads delivered at a mean 38.8± standard deviation of 1.7 weeks’ gestation, although non-Hispanic white and non-Hispanic black, non-Hispanic black and non-Hispanic white, and non-Hispanic black and non-Hispanic black dyads delivered at 38.6±2.0, 38.5±2.3, and 38.3±2.4 weeks’ gestation, respectively (P<.001). Adjusted odds ratios for the association between maternal or paternal race and preterm birth were highest for non-Hispanic black and non-Hispanic black dyads at each gestational age cutoff: adjusted odds ratio, 1.60 (95% confidence interval, 1.11–1.19) (<37 weeks’ gestation); adjusted odds ratio, 2.47 (95% confidence interval, 2.41–2.53) (<34 weeks’ gestation); and adjusted odds ratio, 4.22 (95% confidence interval, 4.04–4.41) (<28 weeks’ gestation) compared with the non-Hispanic white referent group. Models adjusted for insurance status, chronic hypertension, tobacco use during pregnancy, history of previous preterm birth, and male fetus. In the Kaplan-Meier survival analysis, non-Hispanic black and non-Hispanic black dyads delivered the earliest across the range of delivery gestational ages compared with all other combinations of dyads. Non-Hispanic black paternal race is a risk factor for preterm birth and should be considered when evaluating maternal a priori risk of prematurity. Future research should investigate the mechanisms behind this finding, including determining the contribution of factors, such as racism, maternal and paternal genetics, and epigenetics to an individual’s risk of preterm birth.
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影响因子：
9.8
作者：
Smid, Marcela C.;Lee, Jong Hyung;Manuck, Tracy A.
通讯作者：
Manuck, Tracy A.
影响因子：
5.6
作者：
Zollinger, TW;Przybylski, MJ;Gamache, RE
通讯作者：
Gamache, RE
DOI：
10.1080/0167482x.2017.1398725
发表时间：
2019-03
期刊：
Journal of psychosomatic obstetrics and gynaecology
影响因子：
--
作者：
Surkan PJ;Dong L;Ji Y;Hong X;Ji H;Kimmel M;Tang WY;Wang X
通讯作者：
Wang X
影响因子：
3.3
作者：
Li Y;Luo Z;Holzman C;Liu H;Margerison CE
通讯作者：
Margerison CE
影响因子：
2.3
作者：
Howland, Renata E.;Mulready-Ward, Candace;Tong, Van T.
通讯作者：
Tong, Van T.