Purinergic neurotransmission in the gustatory system.

Purinergic neurotransmission in the gustatory system.
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DOI:
10.1016/j.autneu.2021.102874
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发表时间:
2021-12
期刊:
Autonomic neuroscience : basic & clinical
影响因子:
--
通讯作者:
Kinnamon S
Kinnamon S
中科院分区:
其他
文献类型:
--
作者:
Finger T;Kinnamon S

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味蕾由专门的上皮细胞组成,其检测特定的促味剂并与支配内器官的传入味觉神经形成突触。由味觉细胞释放到神经纤维上的神经递质的性质在本世纪早期是神秘的,尽管用于其他感觉感受器细胞类型(例如毛细胞、光感受器)的神经递质至少在十年前就已为人所知。1999年,Burnstock及其同事发表了一篇论文,表明传入神经上存在P2 X受体,这为研究提供了一个跳板,最终发现ATP是味觉系统中至关重要的神经递质。随后的工作表明,味觉细胞亚群利用独特的释放通道CALHM 1/3以电压依赖性方式释放ATP。尽管有这些进展,在这个系统中的嘌呤能传输的几个方面仍有待阐明。
Taste buds consist of specialized epithelial cells which detect particular tastants and synapse onto the afferent taste nerve innervating the endorgan. The nature of the neurotransmitter released by taste cells onto the nerve fiber was enigmatic early in this century although neurotransmitters for other sensory receptor cell types, e.g. hair cells, photoreceptors, was known for at least a decade. A 1999 paper by Burnstock and co-workers showing the presence of P2X receptors on the afferent nerves served as a springboard for research that ultimately led to the discovery of ATP as the crucial neurotransmitter in the taste system. Subsequent work showed that a subpopulation of taste cells utilize a unique release channel, CALHM1/3, to release ATP in a voltage-dependent manner. Despite these advances, several aspects of purinergic transmission in this system remain to be elucidated.
DOI: 10.1679/aohc1950.40.63
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