Effect of estrogen replacement therapy on the ST-segment response to postural and hyperventilation stimuli.

Effect of estrogen replacement therapy on the ST-segment response to postural and hyperventilation stimuli.
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雌激素替代疗法对体位和过度换气刺激 ST 段反应的影响。

DOI:
10.1016/0002-9149(89)90820-5
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发表时间:
1989
期刊:
The American journal of cardiology
影响因子:
--
通讯作者:
Fleg,JL
Fleg,JL
中科院分区:
--
文献类型:
--
作者:
Vaitkevicius,P;Wright,JG;Fleg,JL

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人们普遍认为运动引起的st段异常常发生在冠状动脉正常的女性中。据报道,假阳性运动反应从14%到67%不等。绝经前妇女休息时和运动后st段异常的高频率可能与血浆雌激素水平升高有关。虽然直接验证这一假设是困难的,但雌激素对st段过度通气和体位变化反应的影响可能为这一问题提供深入的见解。这些经常使用的运动前动作被认为会引起独立于心肌缺血的st段移位。我们设计这项研究是为了比较绝经后接受雌激素替代治疗和未接受雌激素替代治疗的妇女坐着、过度通气和站立时st段异常反应的频率。
It is widely recognized that exercise-induced ST-segment abnormalities often occur in women with normal coronary arteries. False-positive exercise responses from 14 to 67% have been reported.1The high frequency of ST-segment abnormalities at rest and in response to exercise in premenopausal women may be explained by their elevated plasma estrogen levels. Although direct testing of this hypothesis is difficult, the effect of estrogen on the ST-segment response to hyperventilation and postural shifts may provide insight into this question. These frequently used preexercise maneuvers are believed to provoke ST-segment shifts independent of myocardial ischemia. We designed this study to compare the frequency of abnormal ST-segment responses to sitting, hyperventilation and standing in postmenopausal women receiving estrogen replacement therapy versus those not receiving it.
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