CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats.
CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats.
复制标题
终纹床核中的 CRF1 和 CRF2 受体调节大鼠对急性束缚应激的心血管反应。
DOI：
10.1016/j.phrs.2015.03.012
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发表时间：
2015
影响因子：
9.3
通讯作者：
C. Crestani
中科院分区：
文献类型：
--
作者：
Leandro A. Oliveira;Jeferson Almeida;R. Benini;C. Crestani
促肾上腺皮质激素释放因子（CRF）通过其在包括终纹床核（BNST）在内的几种边缘系统结构中的作用参与对情绪应激的行为和生理反应。然而，BNST中CRF 1和CRF 2受体在厌恶性威胁时心血管调节中的作用尚不清楚。因此，在本研究中，我们调查的参与CRF受体内的BNST在急性束缚应激引起的心血管反应大鼠。为此，我们评估了双侧BNST与CRF 1或CRF 2受体的选择性激动剂和拮抗剂在束缚应激引起的动脉压和心率增加以及尾部皮肤温度降低中的作用。BNST内微量注射选择性CRF 1受体拮抗剂CP 376395可减轻束缚引起的升压反应和心动过速反应。相反，BNST治疗与选择性CRF 1受体激动剂CRF增加约束诱发的动脉压和HR反应，并减少尾部皮肤温度的下降反应。CRF的所有作用均被CP 376395局部BNST预处理抑制。选择性CRF 2受体拮抗剂antisalvagine-30可降低动脉压升高和尾部皮肤温度下降。选择性CRF 2受体激动剂urocortin-3增加了束缚诱发的升压和心动过速反应，并减少了皮肤温度的下降。尿皮质素-3的所有影响被取消的局部BNST预处理antisalvagine-30。这些结果表明，在情绪应激过程中，BNST中的CRF 1和CRF 2受体都参与了心血管调节。
The corticotropin-releasing factor (CRF) is involved in behavioral and physiological responses to emotional stress through its action in several limbic structures, including the bed nucleus of the stria terminalis (BNST). Nevertheless, the role of CRF1and CRF2receptors in the BNST in cardiovascular adjustments during aversive threat is unknown. Therefore, in the present study we investigated the involvement of CRF receptors within the BNST in cardiovascular responses evoked by acute restraint stress in rats. For this, we evaluated the effects of bilateral treatment of the BNST with selective agonists and antagonists of either CRF1or CRF2receptors in the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by restraint stress. Microinjection of the selective CRF1receptor antagonist CP376395 into the BNST reduced the pressor and tachycardiac responses caused by restraint. Conversely, BNST treatment with the selective CRF1receptor agonist CRF increased restraint-evoked arterial pressure and HR responses and reduced the fall in tail skin temperature response. All effects of CRF were inhibited by local BNST pretreatment with CP376395. The selective CRF2receptor antagonist antisalvagine-30 reduced the arterial pressure increase and the fall in tail skin temperature. The selective CRF2receptor agonist urocortin-3 increased restraint-evoked pressor and tachycardiac responses and reduced the drop in cutaneous temperature. All effects of urocortin-3 were abolished by local BNST pretreatment with antisalvagine-30. These findings indicate an involvement of both CRF1and CRF2receptors in the BNST in cardiovascular adjustments during emotional stress.
DOI：
10.1152/ajpheart.01044.2008
发表时间：
2009-02
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Takeshi Nakamura;Kazumi Kawabe;H. Sapru
通讯作者：
Takeshi Nakamura;Kazumi Kawabe;H. Sapru
影响因子：
4.1
作者：
SWANSON, LW;SAWCHENKO, PE;VALE, WW
通讯作者：
VALE, WW