Hindbrain regional growth in preterm newborns and its impairment in relation to brain injury.
Hindbrain regional growth in preterm newborns and its impairment in relation to brain injury.
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DOI：
10.1002/hbm.23058
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发表时间：
2016-02
影响因子：
4.8
通讯作者：
Barkovich, A. James
中科院分区：
文献类型：
--
作者：
Kim, Hosung;Gano, Dawn;Ho, Mai-Lan;Guo, Xiaoyue M.;Unzueta, Alisa;Hess, Christopher;Ferriero, Donna M.;Xu, Duan;Barkovich, A. James
早产影响全球约11.1%的新生儿，是存活婴儿神经发育障碍的风险因素。组织学研究表明，后脑的亚部发育有差异，尤其是在妊娠晚期。在这一时期发生的早产相关脑损伤可能选择性地影响后脑发育更快的区域，从而伴随着特定区域的生长障碍和最终的神经发育缺陷。本研究旨在量化早产儿小脑和脑干的区域生长（n=65，单独多次扫描）。我们探讨了区域体积与脑损伤严重程度的关系。在没有损伤影像学证据的新生儿中，我们使用混合效应线性模型进行的分析显示，脑桥和小脑前/后叶的外侧凸性生长更快。发现不同的生长障碍模式与早期脑室内出血和小脑出血有关（p<0.05），这可能解释了神经发生中断的不同机制。我们研究中发现的小脑生长模式与仅在组织学数据中观察到的围产期发育中小脑形态发生的细节非常一致。我们提出的分析框架可以为神经发育结果提供预测性成像生物标志物，从而能够早期识别和治疗高危患者。
Premature birth globally affects about 11.1% of all newborns and is a risk factor for neurodevelopmental disability in surviving infants. Histology has suggested that hindbrain subdivisions grow differentially, especially in the third trimester. Prematurity-related brain injuries occurring in this period may selectively affect more rapidly developing areas of hindbrain, thus accompanying region-specific impairments in growth and ultimately neurodevelopmental deficits. The current study aimed to quantify regional growth of the cerebellum and the brainstem in preterm neonates (n=65 with individually multiple scans). We probed associations of the regional volumes with severity of brain injury. In neonates with no imaging evidence of injury, our analysis using a mixed-effect linear model showed faster growth in the pons and the lateral convexity of anterior/posterior cerebellar lobes. Different patterns of growth impairment were found in relation to early cerebral intraventricular hemorrhage and cerebellar hemorrhage (p<0.05), likely explaining different mechanisms through which neurogenesis is disrupted. The pattern of cerebellar growth identified in our study agreed excellently with details of cerebellar morphogenesis in perinatal development, which has only been observed in histological data. Our proposed analytic framework may provide predictive imaging biomarkers for neurodevelopmental outcome, enabling early identification and treatment of high-risk patients.
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影响因子：
29
作者：
Holland D;Chang L;Ernst TM;Curran M;Buchthal SD;Alicata D;Skranes J;Johansen H;Hernandez A;Yamakawa R;Kuperman JM;Dale AM
通讯作者：
Dale AM
影响因子：
3.4
作者：
Kim, Hosung;Mansi, Tommaso;Bernasconi, Neda
通讯作者：
Bernasconi, Neda
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.6
作者：
Joo, Eun Yeon;Kim, Hosung;Hong, Seung Bong
通讯作者：
Hong, Seung Bong