Bronchiolar adenoma/ciliated muconodular papillary tumor mixed with adenocarcinoma in situ in the same tumor.
Bronchiolar adenoma/ciliated muconodular papillary tumor mixed with adenocarcinoma in situ in the same tumor.
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DOI：
10.1111/1759-7714.14784
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发表时间：
2023-02
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Bronchiolar adenoma (BA)/ciliated muconodular papillary tumor (CMPT) is defined as a benign tumor composed of epithelial and basal cells. Recently, some cases with driver mutations or malignant transformation have been observed. Thus, whether BA/CMPT is benign or malignant remains controversial. We herein report an extremely rare case of a 68‐year‐old woman with a CMPT accompanied by adenocarcinoma in situ (AIS). BA/CMPT existed inside the AIS. The BA/CMPT component did not show any driver mutations; however, the AIS component had an EGFR driver mutation in exon 19. The accumulation of cases and further studies are needed to discuss the malignant potential of BA/CMPT. We report an extremely rare case involving mixed BA/CMPT and AIS in the same tumor. In our case, the AIS component had an EGFR driver mutation in exon 19. No driver mutations were detected in the BA/CMPT component. The tumor boundaries between BA/CMPT and AIS were relatively clear. Driver mutations or malignant transformation in BA/CMPT have been reported in several cases, but the present case, it is thought that the two tumors were incidentally mixed. The malignant potential of BA/CMPT should also be considered.
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DOI：
10.1097/pas.0000000000001086
发表时间：
2018-08
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Chang JC;Montecalvo J;Borsu L;Lu S;Larsen BT;Wallace WD;Sae-Ow W;Mackinnon AC;Kim HR;Bowman A;Sauter JL;Arcila ME;Ladanyi M;Travis WD;Rekhtman N
通讯作者：
Rekhtman N
影响因子：
1.2
作者：
Wang, Feng;Shen, Ming-Hong;Lv, Jing-Huan
通讯作者：
Lv, Jing-Huan
影响因子：
4
作者：
Han X;Hao J;Ding S;Wang EH;Wang L
通讯作者：
Wang L
影响因子：
3.1
作者：
Zhao L;Willson CM;Givens NT;Zhu Z;Wakefield MR;Wang Y;Yang W;Fang Y
通讯作者：
Fang Y
影响因子：
1.6
作者：
Li X;Wu Y;Hui D;Luo X;Wu W;Zhang J;Chen H
通讯作者：
Chen H