A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers.
A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers.
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DOI：
10.1371/journal.pone.0088774
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Abnet CC
中科院分区：
文献类型：
--
作者：
Dawsey SP;Hollenbeck A;Schatzkin A;Abnet CC
我们在NIH-AARP饮食与健康研究队列中研究了使用多种维生素或单一维生素/矿物质补充剂与四种上消化道癌症风险的相关性，随访时间为11年。排除后，490，593人被纳入我们的分析队列，1780例上消化道癌症。使用校正潜在混杂因素的考克斯模型计算风险比（HR）和95%置信区间（CI）。我们观察到，在粗模型或调整模型中，多种维生素的使用与四种癌症结局的风险之间没有显著相关性。在个体维生素或矿物质补充剂中，使用铁补充剂与食管腺癌风险显著降低（HR = 0.68，95%CI = 0.49至0.94）和胃非贲门腺癌风险显著增加（HR = 1.59，95%CI = 1.24至2.05）相关。 对于胃非贲门腺癌，我们观察到与锌使用（HR = 1.28，95%CI = 1.01至1.62）和维生素C使用（HR = 0.79，95%CI = 0.65至0.96）相关。 钙的使用，其中一些被报告为抗酸剂并用于治疗反流病，与食管腺癌（HR = 1.27，95% CI = 1.06至1.52）和贲门腺癌（HR = 1.27，95% CI = 1.03至1.56）癌症的风险较高相关。 我们没有看到证据表明复合维生素的使用与四种高致命性上消化道癌症的风险降低有关，但报告使用个别补充剂的风险存在一些差异。
We examined the association of use of multivitamins or single vitamin/mineral supplements with risk of four upper gastrointestinal cancers in the NIH-AARP Diet and Health Study cohort with 11 years of follow-up. After exclusions, 490,593 persons were included in our analytic cohort and 1780 upper gastrointestinal cancers were accrued. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox models with adjustment for potential confounders. We observed no significant associations between multivitamin use and risk for the four cancer outcomes in crude or adjusted models. Among individual vitamin or mineral supplements, use of iron supplements was associated with significantly lower risk of esophageal adenocarcinoma (HR = 0.68, 95% CI = 0.49 to 0.94) and a significantly increased risk of gastric noncardia adenocarcinoma (HR = 1.59, 95% CI = 1.24 to 2.05). For gastric noncardia adenocarcinoma, we saw associations with zinc use (HR = 1.28, 95% CI = 1.01 to 1.62) and vitamin C use (HR = 0.79 95% CI = 0.65 to 0.96). Calcium use, some of which was reported as antacids and used to treat reflux disease, was associated with higher risk of esophageal adenocarcinoma (HR = 1.27, 95% CI = 1.06 to 1.52) and gastric cardia adenocarcinoma (HR = 1.27, 95% CI = 1.03 to 1.56) cancers. We saw no evidence that multivitamin use was associated with reduced risk of four highly fatal upper gastrointestinal cancers, but there were some differences in risk with reported use of individual supplements.
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影响因子：
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作者：
Freedman, Neal D.;Abnet, Christian C.;Schatzkin, Arthur
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