Dynamic expression of two thrombospondins during axolotl limb regeneration.
Dynamic expression of two thrombospondins during axolotl limb regeneration.
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DOI：
10.1002/dvdy.22548
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发表时间：
2011-05
影响因子：
2.5
通讯作者：
Tabin, Clifford J.
中科院分区：
文献类型：
--
作者：
Whited, Jessica L.;Lehoczky, Jessica A.;Austin, Christina A.;Tabin, Clifford J.
再生背后的分子过程在很大程度上仍然未知。通过关注最初在发育背景下发现的基因的再生功能，已经阐明了几个潜在的因素。一个补充的方法是考虑在伤口愈合中所涉及的因素的作用。在这里，我们专注于血栓反应蛋白，一个家族分泌的细胞外基质蛋白已涉及皮肤伤口愈合在哺乳动物。我们表明，在蝾螈肢体再生过程中，血栓反应蛋白的一个子集在不同的时间和特定的细胞类型中表达。我们的研究表明，在蝾螈肢体再生过程中，血栓spondin-1（tsp-1）和血栓spondin-4 （tsp-4）同源基因在肢体再生过程中高度上调，其模式与幼虫肢体发育的模式不同且相似。我们的数据表明，血栓反应蛋白可能是蝾螈肢体再生的关键调节因子，而它们的激活似乎只局限于失去肢体再生能力的脊椎动物的伤口愈合。
The molecular processes underlying regeneration remain largely unknown. Several potential factors have been elucidated by focusing on the regenerative function of genes originally identified in a developmental context. A complementary approach is to consider the roles of factors involved in wound healing. Here we focus on the Thrombospondins, a family of secreted extracellular matrix proteins that have been implicated in skin wound healing in mammals. We show that a subset of Thrombospondins are expressed at distinct times and in particular cell types during axolotl limb regeneration. Our studies have revealed the axolotl orthologs of thrombospondin-1(tsp-1) and thrombospondin-4 (tsp-4) are highly upregulated during limb regeneration in patterns both distinct and similar to larval limb development. Our data suggests that thrombospondins may be key regulators of limb regeneration in axolotl, while their activation appears to be relegated solely to wound healing in vertebrates that have lost the ability to regenerate limbs.
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影响因子：
2.7
作者：
Vinarsky, V;Atkinson, DL;Odelberg, SJ
通讯作者：
Odelberg, SJ
DOI：
10.1073/pnas.0502979102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Ridnour, LA;Isenberg, JS;Wink, DA
通讯作者：
Wink, DA
影响因子：
2.6
作者：
Chanana, Bhavna;Graf, Roland;Vorbrueggen, Gerd
通讯作者：
Vorbrueggen, Gerd
影响因子：
64.8
作者：
SMITH, AR;WOLPERT, L
通讯作者：
WOLPERT, L
再生Axolotl肢体中胚泡形成的蛋白质组学分析。
影响因子：
5.4
作者：
Rao N;Jhamb D;Milner DJ;Li B;Song F;Wang M;Voss SR;Palakal M;King MW;Saranjami B;Nye HL;Cameron JA;Stocum DL
通讯作者：
Stocum DL