Evidence of an inhibitory restraint of seizure activity in humans.
Evidence of an inhibitory restraint of seizure activity in humans.
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DOI：
10.1038/ncomms2056
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发表时间：
2012
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
癫痫发作活动的位置和轨迹是非常重要的，但我们绘制这种活动的地图的能力仍然很原始。最近，用于人体的多电极阵列的发展为记录癫痫发作提供了新的时间和空间分辨率水平。在这里，我们显示出强烈的、超同步的射击表明征募到扣押的区域和只有低水平的、无组织的射击的邻近领土之间的清晰界限。因此，有一个核心领域的招募神经元和周围的“发作半影区”。发作半影区的主要特征是大幅值脑电信号与低水平放电之间的对比。我们的人类录音与抑制抑制的动物研究有着惊人的相似之处，表明它们可以很容易地从这一机制方面得到理解。这些发现对我们如何定位癫痫发作活动并绘制其扩散图具有重要意义。大脑中的癫痫活动以皮质神经元活动的招募为特征。Schevon和他的同事研究了人类受试者的癫痫活动，发现神经元的招募是超同步的，而且这种活动的传播存在内在的抑制。
The location and trajectory of seizure activity is of great importance, yet our ability to map such activity remains primitive. Recently, the development of multi-electrode arrays for use in humans has provided new levels of temporal and spatial resolution for recording seizures. Here, we show that there is a sharp delineation between areas showing intense, hypersynchronous firing indicative of recruitment to the seizure, and adjacent territories where there is only low-level, unstructured firing. Thus, there is a core territory of recruited neurons and a surrounding 'ictal penumbra'. The defining feature of the 'ictal penumbra' is the contrast between the large amplitude EEG signals and the low-level firing there. Our human recordings bear striking similarities with animal studies of an inhibitory restraint, indicating that they can be readily understood in terms of this mechanism. These findings have important implications for how we localize seizure activity and map its spread. Seizure activity in the brain is characterized by the recruitment of cortical neuronal activity. Schevon and colleagues study seizure activity in human subjects and find that the recruitment of neurons is hypersynchronous and that there is an intrinsic restraint on the propagation of this activity.
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