Voltammetric determination of dopamine in the presence of ascorbic acid at over-oxidized polypyrrole-indigo carmine film-coated electrodes.
Voltammetric determination of dopamine in the presence of ascorbic acid at over-oxidized polypyrrole-indigo carmine film-coated electrodes.
复制标题
在抗坏血酸存在下，在过氧化的聚吡咯-靛蓝胭脂红薄膜涂层电极上伏安法测定多巴胺。
DOI：
10.1039/an9941900459
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Minxian Zi
中科院分区：
文献类型：
--
作者：
Zhiqiang Gao;Beshen Chen;Minxian Zi
靛蓝胭脂红掺杂的过氧化聚吡咯膜（PPy-IC）对多巴胺的伏安灵敏度和选择性提供了实质性的改善。这种聚合物涂层衰减抗坏血酸的伏安响应，而多巴胺的氧化峰电流提高了一个数量级以上的裸电极相比。多巴胺的高灵敏度和选择性似乎主要是由于电荷歧视和分析物积累。检测限与膜厚和富集时间有关。在0.25 μ m厚的聚吡咯-离子交换膜涂层电极上，预富集2分钟，检测限为10（-8）mol·l ~（-1），比裸玻碳电极低两个数量级以上。伴随的抗坏血酸显示没有干扰，虽然它的浓度高达0.1 mmol l-1。考察了各种实验参数对多巴胺伏安响应的影响。PPy-IC膜的选择性渗透和预浓缩特性使其对体内电化学有价值。
Over-oxidized polypyrrole films doped with indigo carmine (PPy-IC) offer substantial improvements in voltammetric sensitivity and selectivity towards dopamine. This polymer coating attenuates the voltammetric response of ascorbic acid while the oxidation peak current of dopamine is enhanced by over one order of magnitude compared with that at the bare electrode. The high sensitivity and selectivity for dopamine appears to be mainly due to the charge discrimination and the analyte accumulation. The detection limit is dependent on both film thickness and preconcentration time. At a 0.25 micron thick PPy-IC film-coated electrode, for a 2 min preconcentration time, the detection limit is 10(-8) mol l-1, over two orders of magnitude lower than at a bare glassy carbon electrode. The concomitant ascorbic acid shows no interference although its concentration is as high as 0.1 mmol l-1. The effects of various experimental parameters on the voltammetric response of dopamine were also investigated. The attractive permselective and preconcentrating properties of the PPy-IC films make them valuable for in vivo electrochemistry.
影响因子：
7.4
作者：
Zimmerman Jb;Wightman Rm
通讯作者：
Zimmerman Jb;Wightman Rm
影响因子：
7.4
作者：
KRISTENSEN, EW;KUHR, WG;WIGHTMAN, RM
通讯作者：
WIGHTMAN, RM