Glucose 6-phosphate alters rat skeletal muscle contractile apparatus and sarcoplasmic reticulum function.
Glucose 6-phosphate alters rat skeletal muscle contractile apparatus and sarcoplasmic reticulum function.
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6-磷酸葡萄糖改变大鼠骨骼肌收缩装置和肌浆网功能。
DOI：
10.1113/expphysiol.1998.sp004132
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发表时间：
1998
影响因子：
2.7
通讯作者：
Klug,GA
中科院分区：
文献类型：
--
作者：
Williams,JH;Ward,CW;Spangenburg,EE;Nelson,R;Stavrianeas,S;Klug,GA
We investigated the effects of glucose 6-phosphate (G6P) on skeletal muscle contractile apparatus and sarcoplasmic reticulum (SR) function. Using rat extensor digitorum longus fibres, the presence of 5 mM G6P decreased the Ca2+ sensitivity of both force production and actomyosin ATPase (AM-ATPase) activity. Conversely, maximal Ca2+-activated force was unaffected while maximal AM-ATPase activity was increased by 37 %. In SR vesicles isolated from rat gastrocnemius, G6P markedly altered Ca2+ handling. It increased Ca2+-stimulated Ca2+-ATPase activity but depressed the net rate of Ca2+ uptake. This latter effect appears to be due to G6P-stimulated Ca2+ release. When G6P was added to Ca2+-loaded vesicles, a small, transient release of Ca2+ was elicited. In addition, G6P lowered the threshold for Ca2+-induced Ca2+ release but depressed the net rates of both AgNO3- and caffeine-induced releases. It is possible that the accumulation of G6P during muscular activity may adversely affect muscle force production and contribute to the fatigue process via its action on the contractile apparatus and SR.
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作者：
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DOI：
--
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1985-03
期刊：
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影响因子：
3.3
作者：
S. Byrd;A. K. Bode;G. Klug
通讯作者：
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长时间运动会引起大鼠肌肉 SR Ca(2 )-ATPase 的结构变化。
DOI：
10.1016/0885-4505(91)90087-2
发表时间：
1991
期刊：
Biochemical medicine and metabolic biology
影响因子：
--
作者：
Luckin,KA;Favero,TG;Klug,GA
通讯作者：
Klug,GA