Prevalence of and factors associated with anal high-risk human papillomavirus in urban Tanzanian men who have sex with men, 2011-2012.
Prevalence of and factors associated with anal high-risk human papillomavirus in urban Tanzanian men who have sex with men, 2011-2012.
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DOI：
10.1177/09564624221094456
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发表时间：
2022-06
影响因子：
1.4
通讯作者：
中科院分区：
文献类型：
--
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背景：肛门癌主要由高危人乳头瘤病毒（hrHPV）引起，与HIV感染有关，在男男性行为者（MSM）中发病率非常高。我们评估了在坦桑尼亚达累斯萨拉姆从hiv阳性和hiv阴性的男男性接触者中收集的肛管标本中hrHPV的患病率以及与hrHPV相关的因素。方法：在横断面研究中，采用受访者驱动的抽样方法招募男男性行为者。这项116例MSM的辅助分析的主要结果是HPV-16和其他hrHPV类型的患病率。流行率（PR）估计了hrHPV与hiv阴性参与者的人口统计学、性行为和性传播感染之间的关系。结果：中位年龄为23岁，33.6%的参与者为hiv阳性。HrHPV和HPV-16的患病率分别为54.3%和17.2%，其中hiv阳性男同性恋者的HPV-16患病率最高（36.1%），hiv阴性男同性恋者的HPV-16患病率最低（2.9%）。在hiv阴性的MSM中，在过去一个月内有两个或两个以上的肛交伴侣与hrHPV相关（PR 3.20, 95%CI 1.69-6.07, vs. 0个伴侣）。结论：达累斯萨拉姆的男男性行为者中HrHPV患病率较高，在hiv阳性的男同性恋者中最高。这些估计可用于支持HPV疫苗接种和筛查举措。
Background: Anal cancer is primarily caused by high-risk human papillomavirus (hrHPV), is associated with HIV infection, and has a very high incidence among men who have sex with men (MSM). We assessed prevalence of hrHPV, and factors associated with hrHPV in anal canal specimens collected in Dar es Salaam, Tanzania from HIV-positive and HIV-negative MSM. Methods: MSM were recruited using respondent-driven sampling in this cross-sectional study. The primary outcome in this ancillary analysis of 116 MSM was prevalence of HPV-16 and other hrHPV types. Prevalence ratios (PR) estimated the association between hrHPV and HIV-negative participants’ demographics, sexual behaviour and sexually transmitted infections. Results: Median age was 23 years and 33.6% of participants were HIV-positive. HrHPV and HPV-16 prevalence was 54.3% and 17.2%, respectively, with HPV-16 prevalence highest among HIV-positive MSM identifying as gay (36.1%) and lowest among HIV-negative MSM identifying as bisexual (2.9%). Having two or more receptive anal sex partners in the past month was associated with hrHPV (PR 3.20, 95%CI 1.69-6.07, vs. 0 partners) among HIV-negative MSM.Conclusions: HrHPV prevalence was high among MSM in Dar es Salaam and highest among HIV-positive MSM identifying as gay. These estimates may be used to support HPV vaccination and screening initiatives.
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影响因子：
4.5
作者：
Katanga JJ;Rasch V;Manongi R;Pembe AB;Mwaiselage JD;Kjaer SK
通讯作者：
Kjaer SK
影响因子：
3.7
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Müller EE;Rebe K;Chirwa TF;Struthers H;McIntyre J;Lewis DA
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Lewis DA
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3.7
作者：
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通讯作者：
Jay, Naomi
影响因子：
6.4
作者：
Clifford GM;Georges D;Shiels MS;Engels EA;Albuquerque A;Poynten IM;de Pokomandy A;Easson AM;Stier EA
通讯作者：
Stier EA
影响因子：
4.5
作者：
Mgopa LR;Rosser BRS;Ross MW;Lukumay GG;Mohammed I;Massae AF;Leshabari S;Mkonyi E;Mushy SE;Mwakawanga DL;Trent M;Wadley J;Bonilla ZE
通讯作者：
Bonilla ZE