Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation.
Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation.
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DOI：
10.1371/journal.pone.0060728
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Brey EM
中科院分区：
文献类型：
--
作者：
Chiu YC;Kocagöz S;Larson JC;Brey EM
聚乙二醇（PEG）多孔水凝胶已被证明可以促进血管化组织的形成。然而，PEG水凝胶在生理条件下表现出有限的降解，这阻碍了它们在组织工程治疗中的最终适用性。将聚l -乳酸（PLLA）链引入到聚乙二醇骨架中会导致共聚物通过水解降解，这在一定程度上可以通过共聚物的条件来控制。在本研究中，通过溶剂铸造/颗粒浸出和光聚合制备了多孔的PEG-PLLA水凝胶。研究了聚合物条件对水凝胶结构、降解和力学性能的影响。水凝胶显示的自身荧光允许在完全膨胀条件下对水凝胶结构进行三维、非破坏性监测。初始孔径大小与颗粒大小无关，而降解时间与聚合物浓度有关。压缩模量是聚合物浓度的函数，随着水凝胶的降解而降低。有趣的是，与在其他聚合物体系中观察到的相反，孔径在降解过程中没有变化。这些结果为制备多孔、可降解的PEG-PLLA水凝胶提供了一种技术，并深入了解了降解、结构和机械性能如何取决于合成条件。
Porous hydrogels of poly(ethylene glycol) (PEG) have been shown to facilitate vascularized tissue formation. However, PEG hydrogels exhibit limited degradation under physiological conditions which hinders their ultimate applicability for tissue engineering therapies. Introduction of poly(L-lactic acid) (PLLA) chains into the PEG backbone results in copolymers that exhibit degradation via hydrolysis that can be controlled, in part, by the copolymer conditions. In this study, porous, PEG-PLLA hydrogels were generated by solvent casting/particulate leaching and photopolymerization. The influence of polymer conditions on hydrogel architecture, degradation and mechanical properties was investigated. Autofluorescence exhibited by the hydrogels allowed for three-dimensional, non-destructive monitoring of hydrogel structure under fully swelled conditions. The initial pore size depended on particulate size but not polymer concentration, while degradation time was dependent on polymer concentration. Compressive modulus was a function of polymer concentration and decreased as the hydrogels degraded. Interestingly, pore size did not vary during degradation contrary to what has been observed in other polymer systems. These results provide a technique for generating porous, degradable PEG-PLLA hydrogels and insight into how the degradation, structure, and mechanical properties depend on synthesis conditions.
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影响因子：
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