Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer
Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer
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诊断前列腺癌后前九个月内健康相关生活质量的变化
DOI：
10.1038/sj.pcan.4500228
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发表时间：
1998
影响因子：
4.8
通讯作者：
Peter R. Carroll
中科院分区：
文献类型：
--
作者：
David F. Penson;M. Litwin;D. Lubeck;S. Flanders;D. Pasta;Peter R. Carroll
健康相关生活质量（HRQOL）是前列腺癌研究中的一项重要结局指标。关于社会人口学变量（如保险状况、教育水平、婚姻状况或收入）对HRQOL的影响的数据很少。我们研究了这些或其他社会人口统计学和临床变量是否可以预测HRQOL的结果，使用的是一个观察性数据库的前列腺癌患者从广泛的临床实践settings.We研究了131例新诊断的前列腺癌患者，随访至少9个月。患者入组CaPSURETM，这是一个大型的前列腺癌患者观察数据库。在诊断时和9个月后，使用已建立的经验证的仪器测量一般和疾病特异性HRQOL。在基线时记录社会人口统计学数据和合并症计数。多变量回归分析用于确定社会人口学或临床变量是否可预测基线HRQOL或研究期间HRQOL的变化，一些社会人口学和临床变量与HRQOL显著相关。我们发现在诊断后的9个月内，HRQOL的一般和疾病特异性领域均有改善。对于已婚患者，基线时的情感幸福感和家庭功能评分更好（+11.8，P<0.02），但家庭功能在9个月的研究期间下降（-18.5，P=0.0006）。老年患者在HRQOL的几个领域的基线表现略好，但随着时间的推移，HRQOL下降幅度大于年轻患者。合并症增加与基线总体HRQOL较差相关。早期肿瘤分期可预测基线时一般HRQOL领域评分较好。有限的可触及疾病分期（T2 A/T2 B）可预测9个月时性功能和性困扰的恶化（−8.6，P=0.04; −24，P=0.008）。在最初降低后，患者在初步诊断为前列腺癌的9个月内似乎经历了总体和疾病特异性HRQOL的改善。婚姻状况与较好的HRQOL相关，而随着时间的推移，年龄的增长与HRQOL下降更显著相关。尽管在9个月时观察到身体领域的下降，但在基线时观察到较低阶段疾病的患者具有更好的一般HRQOL。这些数据揭示了前列腺癌患者的经历，并表明HRQOL随时间的变化可能以可预测的方式发生。
Health-Related Quality of Life (HRQOL) is an important outcome measure in the study of prostate cancer. There are few data regarding the effect of sociodemographic variables, such as insurance status, educational level, marital status or income, on HRQOL. We examined whether these or other sociodemographic and clinical variables are predictive of HRQOL outcomes using an observational database of prostate cancer patients accrued from a wide array of clinical practice settings.We studied 131 patients with newly-diagnosed prostate cancer who had been followed for at least nine months. Patients were enrolled in CaPSURETM, a large, observational database of patients with prostate cancer. General and disease-specific HRQOL were measured with established, validated instruments at diagnosis and nine months later. Sociodemographic data and co-morbidity counts were recorded at baseline. Multivariate regression analysis was used to determine whether sociodemographic or clinical variables were predictive of baseline HRQOL or HRQOL changes during the study period.Several sociodemographic and clinical variables demonstrated significant associations with HRQOL. We found improvements in general and disease-specific domains of HRQOL during the nine months after diagnosis. For married patients, Emotional Well-Being and Family Functioning scores were better at baseline (+11.8, P<0.02), but Family Functioning declined over the nine month study period (−18.5, P=0.0006). Older patients had slightly better baseline performance in several domains of HRQOL, but experienced greater HRQOL decrements over time than did younger patients. Increasing comorbidity was associated with worse baseline general HRQOL. Early tumor stage was predictive of better scores in general HRQOL domains at baseline. Limited palpable disease stage (T2A/T2B) was predictive of worse Sexual Function and Sexual Bother at nine months (−8.6, P=0.04; −24, P=0.008).After initial decreases, patients appear to experience an improvement in general and disease-specific HRQOL within nine months of initial diagnosis with prostate cancer. Marital status is associated with better HRQOL, while advancing age is associated with more significant HRQOL declines over time. Patients with lower stage disease were noted to have better general HRQOL at baseline, although decreases in the physical domains were noted at nine months. These data shed new light on patients' experience with prostate cancer and suggest that HRQOL outcomes over time may occur in a predictable manner.
患有慢性腹泻的艾滋病毒感染者的生活质量和卫生服务的使用。
DOI：
--
发表时间：
1993
期刊：
Journal of acquired immune deficiency syndromes
影响因子：
--
作者：
Lubeck,DP;Bennett,CL;Mazonson,PD;Fifer,SK;Fries,JF
通讯作者：
Fries,JF
影响因子：
3
作者：
Pryor,DB;Califf,RM;HarrellJr,FE;Hlatky,MA;Lee,KL;Mark,DB;Rosati,RA
通讯作者：
Rosati,RA
影响因子：
2.1
作者：
FOWLER, FJ;BARRY, MJ;WENNBERG, J
通讯作者：
WENNBERG, J