Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation.
Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation.
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DOI：
10.1038/s41387-018-0032-2
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发表时间：
2018-04-25
影响因子：
6.1
通讯作者：
Haluzík M
中科院分区：
文献类型：
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作者：
Cinkajzlová A;Mráz M;Lacinová Z;Kloučková J;Kaválková P;Kratochvílová H;Trachta P;Křížová J;Haluzíková D;Škrha J;Papežová H;Haluzík M
血管生成素样蛋白（ANGPTLs）3和4是参与脂质和葡萄糖代谢调节的循环因子。我们检测了23例肥胖患者、40例肥胖和2型糖尿病（T2 DM）患者、22例神经性厌食症（AN）患者、15例禁食72小时的受试者和12例短肠综合征（SBS）患者的血清ANGPTL 3和4水平，以及极低热量饮食（VLCD）、减肥手术、部分恢复、急性禁食、和肠外营养，以评估它们在代谢调节中的可能作用。无/有T2 DM的肥胖受试者的血清ANGPTL 4水平较高（94.50 ± 9.51和134.19 ± 7.69 vs. 50.34 ± 4.22 ng/ml，p < 0.001），并且相对于健康对照受试者，AN受试者中更低（38.22 ± 4.48对65.80 ± 7.98 ng/ml，p = 0.002），而血清ANGPTL 3水平显示出相反的趋势。营养状况对脂肪组织ANGPTL 3和4 mRNA表达无影响。禁食降低ANGPTL 3水平并增加ANGPTL 4水平，而VLCD仅降低ANGPTL 3水平。AN或SBS患者的减肥手术和再认识对ANGPTL均无影响。多元回归分析确定BMI为ANGPTL 3的独立预测因子; BMI和HbA 1c分别为ANGPTL 4的独立预测因子。总之，我们的数据表明，血清ANGPTL 3和4水平受营养状况和禁食的影响，并可能参与肥胖和AN中存在的代谢紊乱。
Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations. Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 ± 9.51 and 134.19 ± 7.69 vs. 50.34 ± 4.22 ng/ml, p < 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 ± 4.48 vs. 65.80 ± 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. Nutritional status had no effect on ANGPTL3 and 4 mRNA expression in adipose tissue. Fasting decreased ANGPTL3 and increased ANGPTL4 levels, while VLCD reduced only ANGPTL3. Bariatric surgery and realimentation of AN or SBS patients had no effect on either ANGPTL. Multiple regression analysis identified BMI as an independent predictor of ANGPTL3; and BMI and HbA1c as independent predictors of ANGPTL4, respectively. Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and AN.
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DOI：
10.1161/atvbaha.113.302802
发表时间：
2014-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Mehta N;Qamar A;Qu L;Qasim AN;Mehta NN;Reilly MP;Rader DJ
通讯作者：
Rader DJ
影响因子：
6.5
作者：
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通讯作者：
Gromada, Jesper
影响因子：
25.7
作者：
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通讯作者：
George, J
DOI：
10.1073/pnas.0604026103
发表时间：
2006-11-14
影响因子：
11.1
作者：
Sukonina, Valentina;Lookene, Aivar;Olivecrona, Gunilla
通讯作者：
Olivecrona, Gunilla
影响因子：
4.2
作者：
Nakayama, Toshyuki;Hirakawa, Hiroshi;Taguchi, Takashi
通讯作者：
Taguchi, Takashi