Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU.
Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU.
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DOI：
10.3389/fimmu.2021.742631
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发表时间：
2021
影响因子：
7.3
通讯作者：
López-Huertas MR
中科院分区：
文献类型：
--
作者：
Vigón L;García-Pérez J;Rodríguez-Mora S;Torres M;Mateos E;Castillo de la Osa M;Cervero M;Malo De Molina R;Navarro C;Murciano-Antón MA;García-Gutiérrez V;Planelles V;Alcamí J;Pérez-Olmeda M;Coiras M;López-Huertas MR
SARS-CoV-2感染导致COVID-19，在有症状的受试者中，病情从轻度到危重不等。更好地了解最严重结局患者的免疫反应至关重要。在这项研究中，对2020年4月至6月第一次大流行高峰期间在西班牙马德里的医院和初级卫生保健中心招募的61名不同表现的COVID-19患者进行了与SARS-CoV-2引发的体液免疫应答相关的参数分析。受试者被分配为未住院的轻度患者、住院的重度患者或需要ICU帮助的危重患者。危重患者表现出记忆型和浆母细胞表型的B细胞水平显著增强，以及具有中和能力的SARS-CoV-2抗体水平更高，这些抗体在男性中尤其增加。尽管如此，抗体依赖性细胞介导的细胞毒性在这些个体中是有缺陷的。此外，重症COVID-19患者还显示抗疱疹病毒（如CMV、EBV、HSV-1和VZV）的IgG水平升高，以及血浆中可检测到CMV和EBV病毒血症。总而言之，这些结果表明，重症COVID-19患者的免疫应答增强但无效，这使得潜伏疱疹病毒重新激活。在这些患者的临床管理过程中应考虑这些发现，因为它们可能导致SARS-CoV-2感染期间最严重的疾病。
SARS-CoV-2 infection causes COVID-19, ranging from mild to critical disease in symptomatic subjects. It is essential to better understand the immunologic responses occurring in patients with the most severe outcomes. In this study, parameters related to the humoral immune response elicited against SARS-CoV-2 were analysed in 61 patients with different presentations of COVID-19 who were recruited in Hospitals and Primary Healthcare Centres in Madrid, Spain, during the first pandemic peak between April and June 2020. Subjects were allocated as mild patients without hospitalization, severe patients hospitalized or critical patients requiring ICU assistance. Critical patients showed significantly enhanced levels of B cells with memory and plasmablast phenotypes, as well as higher levels of antibodies against SARS-CoV-2 with neutralization ability, which were particularly increased in male gender. Despite all this, antibody-dependent cell-mediated cytotoxicity was defective in these individuals. Besides, patients with critical COVID-19 also showed increased IgG levels against herpesvirus such as CMV, EBV, HSV-1 and VZV, as well as detectable CMV and EBV viremia in plasma. Altogether, these results suggest an enhanced but ineffectual immune response in patients with critical COVID-19 that allowed latent herpesvirus reactivation. These findings should be considered during the clinical management of these patients due to the potential contribution to the most severe disease during SARS-CoV-2 infection.
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影响因子：
7.3
作者：
Fink K
通讯作者：
Fink K
DOI：
10.5501/wjv.v1.i1.31
发表时间：
2012-02-12
期刊：
World journal of virology
影响因子：
--
作者：
De Paschale, Massimo;Clerici, Pierangelo
通讯作者：
Clerici, Pierangelo
DOI：
10.1016/s0140-6736(21)01420-3
发表时间：
2021-07-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Borobia AM;Carcas AJ;Pérez-Olmeda M;Castaño L;Bertran MJ;García-Pérez J;Campins M;Portolés A;González-Pérez M;García Morales MT;Arana-Arri E;Aldea M;Díez-Fuertes F;Fuentes I;Ascaso A;Lora D;Imaz-Ayo N;Barón-Mira LE;Agustí A;Pérez-Ingidua C;Gómez de la Cámara A;Arribas JR;Ochando J;Alcamí J;Belda-Iniesta C;Frías J;CombiVacS Study Group
通讯作者：
CombiVacS Study Group
影响因子：
6.4
作者：
Chisholm, Susan E.;Howard, Keith;Reyburn, Hugh T.
通讯作者：
Reyburn, Hugh T.
影响因子：
17.1
作者：
Furman D;Jojic V;Sharma S;Shen-Orr SS;Angel CJ;Onengut-Gumuscu S;Kidd BA;Maecker HT;Concannon P;Dekker CL;Thomas PG;Davis MM
通讯作者：
Davis MM