COVID-19 vaccine challenges: What have we learned so far and what remains to be done?
COVID-19 vaccine challenges: What have we learned so far and what remains to be done?
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DOI：
10.1016/j.healthpol.2021.03.013
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Mossialos E
中科院分区：
文献类型：
--
作者：
Forman R;Shah S;Jeurissen P;Jit M;Mossialos E
开发和分发安全有效的SARS-CoV-2（COVID-19）疫苗引起了全球的极大兴趣。在COVID-19被宣布为大流行后不到一年，多个国家的几种候选疫苗获得了紧急使用授权。尽管取得了这一科学突破，但从疫苗发现到全球对COVID-19的群体免疫的过程继续带来重大的政策挑战，需要全球合作应对。我们提供了一个框架，以了解成功开展全球COVID-19疫苗接种活动的剩余和新的政策挑战，以及应对这些挑战的潜在解决方案。决策者必须意识到这些挑战，并制定可大规模实施的解决方案。这些挑战包括维持研发激励、开展临床试验、授权、上市后监督、制造和供应、全球传播、分配、吸收和临床系统适应等方面的挑战。除了这些挑战，还必须解决财务和道德问题。
Developing and distributing a safe and effective SARS-CoV-2 (COVID-19) vaccine has garnered immense global interest. Less than a year after COVID-19 was declared a pandemic, several vaccine candidates had received emergency use authorization across a range of countries. Despite this scientific breakthrough, the journey from vaccine discovery to global herd immunity against COVID-19 continues to present significant policy challenges that require a collaborative, global response. We offer a framework for understanding remaining and new policy challenges for successful global vaccine campaigns against COVID-19 as well as potential solutions to address them. Decision-makers must be aware of these challenges and strategize solutions that can be implemented at scale. These include challenges around maintaining R&D incentives, running clinical trials, authorizations, post-market surveillance, manufacturing and supply, global dissemination, allocation, uptake, and clinical system adaption. Alongside these challenges, financial and ethical concerns must also be addressed.
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影响因子：
5.4
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