Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
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作者：
在全基因组RNAi筛选过程中，我们分离到了与果蝇先天免疫反应相关的CG8580基因。我们将CG8580命名为Akirin，它与IMD途径下游的NF-κB转录因子平行发挥作用，是抵御革兰氏阴性菌所必需的。Akirin基因高度保守，人类基因组包含两个同源基因，其中一个能够挽救果蝇细胞功能表型的丧失。Akirins进行了严格的核本地化。对小鼠两种Akirin同源物的敲除表明，其中一种在Toll样受体、肿瘤坏死因子和白介素1-β(IL-1β)信号通路下游具有重要功能，导致IL-6的产生。因此，Akirin是天然免疫反应所需的一种保守的核因子。
During a genome-wide RNAi screen, we isolated CG8580 as a gene involved in the innate immune response of Drosophila. CG8580, which we named Akirin, acts in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria. Akirin is highly conserved and the human genome contains two homologues, one of which was able to rescue the loss of function phenotype in Drosophila cells. Akirins had a strict nuclear localization. Knockout of both Akirin homologues in mice revealed that one had an essential function downstream of Toll-like receptor, tumor necrosis factor and interleukin 1-β (IL-1β) signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses.
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FlyBase：十几个基因组。
影响因子：
14.9
作者：
Crosby MA;Goodman JL;Strelets VB;Zhang P;Gelbart WM;FlyBase Consortium
通讯作者：
FlyBase Consortium
DOI：
10.1073/pnas.0404952102
发表时间：
2005-01-25
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11.1
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通讯作者：
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13.8
作者：
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通讯作者：
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64.5
作者：
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通讯作者：
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作者：
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