Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD.
Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD.
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接受 CAPD/CCPD 的儿科患者肾性骨营养不良的生化标志物。
DOI：
10.1038/ki.1994.31
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发表时间：
1994
影响因子：
19.6
通讯作者：
Goodman,WG
中科院分区：
文献类型：
--
作者：
Salusky,IB;Ramirez,JA;Oppenheim,W;Gales,B;Segre,GV;Goodman,WG
小儿CAPD/CCPD患者肾性骨营养不良的生化指标。评估血清完整甲状旁腺激素[1-84]水平作为诊断CAPD/CCPD患儿肾性骨营养不良的潜在无创方法。55例患者，年龄13±5 （X±SD）岁，接受CAPD/CCPD治疗29±13个月，共获得68份骨活检标本；纤维性骨炎34例，继发性甲状旁腺功能亢进轻度病变6例，动态病变15例，组织学正常13例。骨质不动或骨组织正常的患者血清钙水平高于继发性甲状旁腺功能亢进症患者，而纤维性骨炎患者血清磷、碱性磷酸酶和甲状旁腺素水平较高。血清甲状旁腺激素（PTH）水平bb0 200 pg/ml和血清钙值<10 mg/dl的组合对鉴别骨高周转率病变患者的敏感性为85%，特异性为100%。血清PTH值<200 pg/ml对动态骨患者的敏感性为100%，特异性为79%；然而，使用PTH水平<150 pg/ml和血清钙水平bbb10 mg/dl的联合标准，特异性增加到92%。血清钙水平升高和血清甲状旁腺激素值在正常范围内或低于正常范围是肾性骨营养不良动态病变的特征。血清PTH水平约200 pg/ml可用于区分低周转率肾性骨营养不良患者和继发性甲状旁腺功能亢进患者。
Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD. Serum intact PTH [1–84] levels were evaluated as a potential non-invasive method for the diagnosis of renal osteodystrophy in children treated with CAPD/CCPD. Sixty-eight bone biopsy samples were obtained from 55 patients, aged 13 ± 5 (X ±SD) years, undergoing CAPD/CCPD for 29 ± 13 months; osteitis fibrosa was present in 34 cases, mild lesions of secondary hyperparathyroidism in six, 15 had adynamic lesions, and 13 were classified as normal histology. Serum calcium levels were higher in patients with adynamic bone or normal bone histology than in those with secondary hyperparathyroidism, whereas serum phosphorus, alkaline phosphatase and PTH levels were greater in patients with osteitis fibrosa. The combination of a serum PTH level >200 pg/ml and a serum calcium value <10 mg/dl was 85% sensitive and 100% specific for identifying patients with high-turnover lesions of bone. Serum PTH values <200 pg/ml were 100% sensitive but only 79% specific for patients with adynamic bone; specificity increased to 92%, however, using the combined criteria of a PTH level <150 pg/ml and a serum calcium level >10 mg/dl. Higher serum calcium levels and serum PTH values within or below the normal range characterize patients with the adynamic lesion of renal osteodystrophy. Serum PTH levels of approximately 200 pg/ml are useful for distinguishing patients with low-turnover lesions of renal osteodystrophy from those with secondary hyperparathyroidism.
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影响因子：
5.8
作者：
PITTS, TO;PIRAINO, BH;PUSCHETT, JB
通讯作者：
PUSCHETT, JB
正常志愿者和继发性甲状旁腺功能亢进症患者钙调节甲状旁腺激素分泌的直接体内比较。
DOI：
10.1210/jcem.76.6.8501155
发表时间：
1993
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Ramirez,JA;Goodman,WG;Gornbein,J;Menezes,C;Moulton,L;Segre,GV;Salusky,IB
通讯作者：
Salusky,IB
25-羟基胆钙化醇对终末期肾功能衰竭儿童骨病变的影响。
影响因子：
19.6
作者：
Giulia Witmer;Alina Margolis;Olivier Fontaine;Janine Fritsch;Gérard Lenoir;Michel Broyer;Sonia Balsan
通讯作者：
Sonia Balsan
DOI：
10.1210/jcem-63-5-1163
发表时间：
1986-11
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
D. Andress;D. Endres;N. Maloney;J. Kopp;J. Coburn;D. Sherrard
通讯作者：
D. Andress;D. Endres;N. Maloney;J. Kopp;J. Coburn;D. Sherrard
DOI：
10.1210/jcem-39-1-119
发表时间：
1974
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
D. Sherrard;D. Baylink;J. Wergedal;N. Maloney
通讯作者：
N. Maloney