Intracortical remodeling parameters are associated with measures of bone robustness.
Intracortical remodeling parameters are associated with measures of bone robustness.
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DOI：
10.1002/ar.22962
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发表时间：
2014-10
影响因子：
2
通讯作者：
Jepsen, Karl J.
中科院分区：
文献类型：
--
作者：
Goldman, Haviva M.;Hampson, Naomi A.;Guth, J. Jared;Lin, David;Jepsen, Karl J.
先前的工作确定了骨稳健性和孔隙率之间的新关联，这可能是更广泛的相互作用的一部分，骨骼系统通过调节组织水平的机械特性来补偿稳健性的自然变化（骨宽度相对于长度），以增加细长骨的刚度并减少稳健骨的质量。为了进一步理解这种关联，我们测试了以下假设：稳健性和孔隙率之间的关系是通过皮质内基于BMU（基本多细胞单位）的重塑介导的。我们在人尸体胫骨的两个部位（长度的38%和66%）定量皮质孔隙度、矿化和组织形态学。我们发现稳健性与几个组织形态计量学变量（例如，%次级组织[R2 = 0.68，p < 0.004]，总骨单位面积[R2=0.42，p<0.04]）。尽管这些关联在38%部位较弱，但在这两个部位之间发现了组织学变量之间的显着相关性，表明两者都对相同的整体效应做出反应，并在整个骨骼水平上表现出相似的特征。因此，强健的骨往往具有更大和更多的骨单位，填充更少，导致更大的孔隙和更多的次级骨面积。这些结果表明，基于BMU的重塑的局部调节可以进一步由与鲁棒性相关的全局信号调制，使得重塑在细长骨中被抑制，但在鲁棒骨中不被抑制。进一步阐明这一机制对于更好地理解骨骼的复杂适应性，以及重塑中的个体间差异如何不同地影响骨骼衰老和个体对预防性治疗的潜在反应至关重要。
Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue-level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU-based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38 and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e.g., % secondary tissue [R2 = 0.68, p < 0.004], total osteon area [R2=0.42, p<0.04]) at the 66% site. Although these associations were weaker at the 38% site, significant correlations between histological variables were identified between the two sites indicating that both respond to the same global effects and demonstrate a similar character at the whole bone level. Thus, robust bones tended to have larger and more numerous osteons with less infilling, resulting in bigger pores and more secondary bone area. These results suggest that local regulation of BMU-based remodeling may be further modulated by a global signal associated with robustness, such that remodeling is suppressed in slender bones but not in robust bones. Elucidating this mechanism further is crucial for better understanding the complex adaptive nature of the skeleton, and how inter-individual variation in remodeling differentially impacts skeletal aging and an individuals’ potential response to prophylactic treatments.
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影响因子：
2.4
作者：
Dellanini, L;Hawkins, D;Stover, S
通讯作者：
Stover, S
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
1.5
作者：
BOUVIER, M;HYLANDER, WL
通讯作者：
HYLANDER, WL
DOI：
10.1302/0301-620x.72b3.2341429
发表时间：
1990-05-01
影响因子：
--
作者：
BURR, DB;MILGROM, C;RADIN, EL
通讯作者：
RADIN, EL
影响因子：
2.7
作者：
Ekenman, I;Halvorsen, K;Rolf, C
通讯作者：
Rolf, C