The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy.
The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy.
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DOI：
10.1155/2017/1673081
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发表时间：
2017
影响因子：
4.3
通讯作者：
Miranda-Díaz AG
中科院分区：
文献类型：
--
作者：
Sifuentes-Franco S;Pacheco-Moisés FP;Rodríguez-Carrizalez AD;Miranda-Díaz AG
糖尿病多发神经病变（DPN）是糖尿病（DM）最常见的慢性并发症。持续的高血糖状态导致细胞质和线粒体活性氧（ROS）的产生增加，有利于抗氧化防御的解除，抗氧化防御能够激活多种代谢途径，从而触发硝基氧化应激（NOS）和内质网应激的存在。高血糖引起微血管和大血管并发症的出现，有利于大分子（脂质、碳水化合物和蛋白质）的氧化损伤，导致损伤DNA的产物增加。高血糖导致线粒体功能障碍，线粒体分裂/融合和调节因子之间的失调。线粒体分裂出现在糖尿病神经病变早期，有能力促进线粒体断裂。自噬是由氧化应激诱导的分解代谢过程，涉及溶酶体形成囊泡。自噬保护细胞免受各种应激因素和常规恶化。阐明糖尿病并发症出现的机制将有助于根据受影响代谢途径的机制选择特定的治疗方案。目前，外源性抗氧化剂在慢性退行性代谢疾病（如糖尿病）中形成辅助治疗选择。
Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable of activating diverse metabolic pathways which trigger the presence of nitro-oxidative stress (NOS) and endoplasmic reticulum stress. Hyperglycemia provokes the appearance of micro- and macrovascular complications and favors oxidative damage to the macromolecules (lipids, carbohydrates, and proteins) with an increase in products that damage the DNA. Hyperglycemia produces mitochondrial dysfunction with deregulation between mitochondrial fission/fusion and regulatory factors. Mitochondrial fission appears early in diabetic neuropathy with the ability to facilitate mitochondrial fragmentation. Autophagy is a catabolic process induced by oxidative stress that involves the formation of vesicles by the lysosomes. Autophagy protects cells from diverse stress factors and routine deterioration. Clarification of the mechanisms involved in the appearance of complications in DM will facilitate the selection of specific therapeutic options based on the mechanisms involved in the metabolic pathways affected. Nowadays, the antioxidant agents consumed exogenously form an adjuvant therapeutic alternative in chronic degenerative metabolic diseases, such as DM.
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影响因子：
16.2
作者：
Albers JW;Herman WH;Pop-Busui R;Feldman EL;Martin CL;Cleary PA;Waberski BH;Lachin JM;Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications Research Group
通讯作者：
Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications Research Group
影响因子：
7.7
作者：
Forbes, JM;Cooper, ME;Osicka, TM
通讯作者：
Osicka, TM
影响因子：
5.6
作者：
de M Bandeira S;da Fonseca LJ;da S Guedes G;Rabelo LA;Goulart MO;Vasconcelos SM
通讯作者：
Vasconcelos SM
影响因子：
4
作者：
Chen, Yongqiang;Klionsky, Daniel J.
通讯作者：
Klionsky, Daniel J.
DOI：
10.1152/ajpendo.00287.2009
发表时间：
2009-09-01
影响因子：
5.1
作者：
Askwith, Trevor;Zeng, Wei;Stevens, Martin J.
通讯作者：
Stevens, Martin J.