Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus.
Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus.
复制标题
DOI：
10.3390/ijms14023265
复制
发表时间：
2013-02-05
影响因子：
5.6
通讯作者：
Vasconcelos SM
中科院分区：
文献类型：
--
作者：
de M Bandeira S;da Fonseca LJ;da S Guedes G;Rabelo LA;Goulart MO;Vasconcelos SM
糖尿病的高流行率及其在世界范围内的发病率不断上升，加上在其携带者中观察到的几种并发症，已成为一个具有重大意义的公共卫生问题。慢性高血糖是这种疾病的主要特征，被认为是造成糖尿病中观察到的微血管和大血管并发症的原因。为了更好地理解这种内分泌疾病过程中涉及的病理生理机制，已经进行了一些努力。最近，许多作者提出，高活性氧和氮的过量产生是高血糖引起的并发症发展的关键因素。这些活性物质的过量产生和/或清除不足会导致血管功能障碍、细胞蛋白、膜脂和核酸的损伤，这促使不同的研究小组寻找能够正确准确测量糖尿病患者氧化应激（OS）的生物标志物，特别是在存在慢性并发症的情况下。面对这种情况，本综述简要阐述了高血糖在OS中的作用，考虑了基本机制及其在糖尿病中的作用，描述了一些更常用的氧化/亚硝化损伤生物标志物，并包括一些评估糖尿病患者OS生物标志物的研究实例，指出这些生物成分与糖尿病携带者一般氧化应激状态的相关性。
The high prevalence of diabetes mellitus and its increasing incidence worldwide, coupled with several complications observed in its carriers, have become a public health issue of great relevance. Chronic hyperglycemia is the main feature of such a disease, being considered the responsible for the establishment of micro and macrovascular complications observed in diabetes. Several efforts have been directed in order to better comprehend the pathophysiological mechanisms involved in the course of this endocrine disease. Recently, numerous authors have suggested that excess generation of highly reactive oxygen and nitrogen species is a key component in the development of complications invoked by hyperglycemia. Overproduction and/or insufficient removal of these reactive species result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids, leading different research groups to search for biomarkers which would be capable of a proper and accurate measurement of the oxidative stress (OS) in diabetic patients, especially in the presence of chronic complications. In the face of this scenario, the present review briefly addresses the role of hyperglycemia in OS, considering basic mechanisms and their effects in diabetes mellitus, describes some of the more commonly used biomarkers of oxidative/nitrosative damage and includes selected examples of studies which evaluated OS biomarkers in patients with diabetes, pointing to the relevance of such biological components in general oxidative stress status of diabetes mellitus carriers.
登录
查看更多内容
影响因子：
9.8
作者：
Bravi, MC;Armiento, A;De Mattia, G
通讯作者：
De Mattia, G
影响因子：
7.7
作者：
Ceriello, A;Morocutti, A;Viberti, GC
通讯作者：
Viberti, GC
影响因子：
2.1
作者：
Genet, Solomon;Lema, Yakobo;Lutale, Janne
通讯作者：
Lutale, Janne
影响因子：
2.5
作者：
Ganesh, Swaminathan;Dharmalingam, Mala;Marcus, Sara Rani
通讯作者：
Marcus, Sara Rani
DOI：
10.1590/s0100-40422006000100021
发表时间：
2006-02-01
期刊：
Química Nova
影响因子：
--
作者：
Barreiros, André L. B. S.;David, Jorge M.;David, Juceni P.
通讯作者：
David, Juceni P.