Brain perivascular space imaging across the human lifespan.
Brain perivascular space imaging across the human lifespan.
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DOI：
10.1016/j.neuroimage.2023.120009
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发表时间：
2023-05-01
期刊：
影响因子：
5.7
通讯作者：
Choupan, Jeiran
中科院分区：
文献类型：
--
作者：
Lynch, Kirsten M.;Sepehrband, Farshid;Toga, Arthur W.;Choupan, Jeiran
血管周围间隙增大(PVS)被认为是血管病理的生物标志物，并在正常衰老和神经疾病中观察到；然而，由于缺乏对PVS随年龄变化的标准时间过程的了解，对PVS在健康和疾病中的作用的研究受到阻碍。为此，我们使用多模式结构MRI数据，在8至90岁的健康受试者的大横断面队列(约1400人)中表征了年龄、性别和认知表现对PVS解剖特征的影响。我们的结果表明，年龄与一生中MRI可见的更广泛和更多的PVS相关，PVS扩大轨迹的空间变化模式。特别是，儿童时期PVS体积分数低的区域与年龄相关的PVS快速扩大相关(例如，颞区)，而儿童时期PVS体积分数较高的区域与年龄相关的PVS改变最小(例如，边缘区域)。与女性相比，男性的PVS负荷显著增加，随着年龄的增长，PVS的形态时间进程不同。综上所述，这些发现有助于我们对健康寿命中血管周围生理学的理解，并为PVS扩大模式的空间分布提供了一个规范的参考，可以与病理变化进行比较。
Enlarged perivascular spaces (PVS) are considered a biomarker for vascular pathology and are observed in normal aging and neurological conditions; however, research on the role of PVS in health and disease are hindered by the lack of knowledge regarding the normative time course of PVS alterations with age. To this end, we characterized the influence of age, sex and cognitive performance on PVS anatomical characteristics in a large cross-sectiona cohort (~1400) of healthy subjects between 8 and 90 years of age using multimodal structural MRI data. Our results show age is associated with wider and more numerous MRI-visible PVS over the course of the lifetime with spatially-varying patterns of PVS enlargement trajectories. In particular, regions with low PVS volume fraction in childhood are associated with rapid age-related PVS enlargement (e.g., temporal regions), while regions with high PVS volume fraction in childhood are associated with minimal age-related PVS alterations (e.g., limbic regions). PVS burden was significantly elevated in males compared to females with differing morphological time courses with age. Together, these findings contribute to our understanding of perivascular physiology across the healthy lifespan and provide a normative reference for the spatial distribution of PVS enlargement patterns to which pathological alterations can be compared.
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DOI：
10.1038/jcbfm.2008.115
发表时间：
2009-02
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1177/0271678x17737984
发表时间：
2018-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Bedussi B;Almasian M;de Vos J;VanBavel E;Bakker EN
通讯作者：
Bakker EN
影响因子：
5.7
作者：
Fischl, B;Salat, DH;Dale, AM
通讯作者：
Dale, AM
影响因子：
8.3
作者：
Doubal, Fergus N.;MacLullich, Alasdair M. J.;Wardlaw, Joanna M.
通讯作者：
Wardlaw, Joanna M.
影响因子：
2.8
作者：
Cha, KS;Kim, MH;Kim, HJ
通讯作者：
Kim, HJ