Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonica, in Sichuan province, China.
Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonica, in Sichuan province, China.
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DOI：
10.1186/s13071-022-05496-0
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发表时间：
2022-10-11
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
钉螺控制是中国血吸虫病防治工作的关键。然而，钉螺的重新出现对血吸虫病防治工作提出了挑战。本研究的目的是测试两栖蜗牛是否可以跨越流域使用人口遗传学和地理统计学相结合的传播。通过全国钉螺调查，获得了钉螺栖息地的数字地图和属性信息。胡平。在四川省45个县（市）进行了钉螺抽样调查。对标本进行cox 1基因测序。独特的单倍型被发现的系统发育推断和映射在地理信息系统（GIS）。利用Monmonier最大差分算法识别基因流动的障碍。在研究区的水道和流域确定的数字高程模型（DEM）的基础上。平原地区以坡度为界限。蜗牛栖息地的坡度的特点和最近的距离水道计算使用GIS平台。通过对钉螺栖息地的密度分析，观察到高密度分布的空间动态。共获得了422条O.从45个采样点获得湖北种标本，并将其分解为128个独特的单倍型或10个分支。在研究区北部观察到较高的单倍型多样性。在整个研究区发现了四个基因流动障碍，导致五个亚区域。四个次区域跨越主要流域，而高密度分布仅限于流域内。结果表明，钉螺能够在低密度区扩散。在坡度< 0.94°的平原区，有63.48%的生境或43.29%的累积受侵害面积。大约90%的蜗牛栖息地更靠近较小的水道。历史上，高密度地区主要分布在平原，而现在更多地分布在丘陵地区。研究结果显示了钉螺在大尺度上的跨流域分布。平原上自然的跨流域传播以及人类和动物的远距离扩散可能是所观察到的模式的主要驱动力。建议采取跨流域联合控制策略控制钉螺和血吸虫病。在线版本包含补充材料，可通过10.1186/s13071-022-05496-0获得。
Snail control is critical to schistosomiasis control efforts in China. However, re-emergence of Oncomelania hupensis is challenging the achievements of schistosomiasis control. The present study aimed to test whether the amphibious snails can spread across watersheds using a combination of population genetics and geographic statistics. The digital maps and attributes of snail habitats were obtained from the national survey on O. hupensis. Snail sampling was performed in 45 counties of Sichuan Province. The cox1 gene of specimens was characterized by sequencing. Unique haplotypes were found for phylogenetic inference and mapped in a geographical information system (GIS). Barriers of gene flow were identified by Monmonier’s maximum difference algorithm. The watercourses and watersheds in the study area were determined based on a digital elevation model (DEM). Plain areas were defined by a threshold of slope. The slope of snail habitats was characterized and the nearest distance to watercourses was calculated using a GIS platform. Spatial dynamics of high-density distributions were observed by density analysis of snail habitats. A total of 422 cox1 sequences of O. hupensis specimens from 45 sampling sites were obtained and collapsed into 128 unique haplotypes or 10 clades. Higher haplotype diversity in the north of the study area was observed. Four barriers to gene flow, leading to five sub-regions, were found across the study area. Four sub-regions ran across major watersheds, while high-density distributions were confined within watersheds. The result indicated that snails were able to disperse across low-density areas. A total of 63.48% habitats or 43.29% accumulated infested areas were distributed in the plain areas where the overall slope was < 0.94°. Approximately 90% of snail habitats were closer to smaller watercourses. Historically, high-density areas were mainly located in the plains, but now more were distributed in hilly region. Our study showed the cross-watershed distribution of Oncomelania snails at a large scale. Natural cross-watershed spread in plains and long-distance dispersal by humans and animals might be the main driver of the observed patterns. We recommend cross-watershed joint control strategies for snail and schistosomiasis control. The online version contains supplementary material available at 10.1186/s13071-022-05496-0.
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影响因子：
3.2
作者：
Li S;Shi Y;Deng W;Ren G;He H;Hu B;Li C;Zhang N;Zheng Y;Wang Y;Dong S;Chen Y;Jiang Q;Zhou Y
通讯作者：
Zhou Y
影响因子：
4.7
作者：
Gong Y;Li Y;Zhang L;Lv S;Xu J;Li S
通讯作者：
Li S
影响因子：
4.9
作者：
Clement, M;Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
7.7
作者：
Excoffier, Laurent;Lischer, Heidi E. L.
通讯作者：
Lischer, Heidi E. L.