The physiological, in-vitro simulation of daily activities in the intervertebral disc using a load Informed kinematic evaluation (LIKE) protocol.
The physiological, in-vitro simulation of daily activities in the intervertebral disc using a load Informed kinematic evaluation (LIKE) protocol.
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使用负载知情运动学评估 (LIKE) 协议对椎间盘日常活动进行生理、体外模拟。
DOI：
10.1016/j.jbiomech.2023.111919
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发表时间：
2024
影响因子：
2.4
通讯作者：
Lazaro-Pacheco D
中科院分区：
文献类型：
--
作者：
Lazaro-Pacheco D
目前的脊柱测试方案通常采用纯力矩结合轴向压缩。然而，日常活动涉及多轴负荷，并且多轴负荷已显示出影响椎间盘（IVD）细胞活力。因此，将体内载荷数据与脊柱模拟器相结合对于了解载荷如何影响IVD至关重要，但由于载荷耦合和可变载荷率，这样做具有挑战性。本研究通过载荷信息运动学评估（LIKE）协议解决了这些挑战，该协议使用每个轴上的期望载荷和实际载荷之间的均方根误差（RMSE）进行评估。第1阶段涉及以降低的测试速度复制20个Orthoload活动，从六轴负载控制测试中获得运动学。第2阶段在五个轴上应用这些运动学，在载荷控制中以降低的速度和生理测试速率施加轴向压缩。第三阶段通过六轴运动控制结合昼夜高度校正进行长期测试，以解释IVD的自然高度波动。第1阶段产生的RMSE在称重传感器噪声基底的两倍内。在第2阶段期间，在减速（Tx：0.80 ± 0.30 N; Ty：0.77 ± 0.29 N; Tz：1.79 ± 0.50 N; Rx：0.02 ± 0.01 Nm; Ry：0.02 ± 0.01 Nm;和Rz：0.02 ± 0.01 Nm）和生理测试速率（Tx：3.45 ± 1.81 N; Ty：3.82 ± 1.99 N; Tz：11.32 ± 8.69 N; Rx：0.13 ± 0.07 Nm; Ry：0.16 ± 0.11 Nm;和Rz：0.07 ± 0.04 Nm）下保持低RMSE。为了解决在较长测试（> 2 h）中观察到的不必要的振荡，引入阶段3以使得能够以生理测试速率稳定且一致地复制活性。尽管RMSE更高，但轴向误差为85.5 ± 24.27 N（相当于10.16 MPa），剪切RMSE与以较慢速率进行纯力矩试验的其他试验系统相似。LIKE方案能够复制生理负荷，为增强IVD机械生物学研究以及IVD器械和治疗的临床前评价提供机会。
Current spinal testing protocols generally adopt pure moments combined with axial compression. However, daily activities involve multi-axis loads, and multi-axis loading has been shown to impact intervertebral disc (IVD) cell viability. Therefore, integrating in-vivo load data with spine simulators is critical to understand how loading affects the IVD, but doing so is challenging due to load coupling and variable load rates. This study addresses these challenges through the Load Informed Kinematic Evaluation (LIKE) protocol, which was evaluated using the root mean squared error (RMSE) between desired and actual loads in each axis. Stage 1 involves obtaining the kinematics from six-axis load control tests replicating 20 Orthoload activities at a reduced test speed. Stage 2 applies these kinematics in five axes, with axial compression applied in load control, at the reduced speed and at the physiological test rate. Stage 3 enables long-term tests through six-axis kinematic control combined with diurnal height correction to account for the natural height fluctuations of the IVD. Stage 1 yielded RMSEs within twice the load cell noise floor. Low RMSEs were maintained during stage 2 at reduced speed (Tx:0.80 ± 0.30 N; Ty:0.77 ± 0.29 N; Tz:1.79 ± 0.50 N; Rx:0.02 ± 0.01Nm; Ry:0.02 ± 0.01Nm; and Rz:0.02 ± 0.01Nm) and at the physiological test rate (Tx:3.45 ± 1.81 N; Ty:3.82 ± 1.99 N; Tz:11.32 ± 8.69 N; Rx:0.13 ± 0.07Nm; Ry:0.16 ± 0.11Nm; and Rz:0.07 ± 0.04Nm). To address unwanted oscillations observed in longer tests (>2h), Stage 3 was introduced to enable the stable and consistent replication of activities at a physiological test rate. Despite higher RMSEs the axial error was 85.5 ± 24.27 N (equivalent to ∼ 0.16 MPa), with shear RMSEs similar to other testing systems conducting pure moment tests at slower rates. The LIKE protocol enables the replication of physiological loads, providing opportunities for enhanced investigations of IVD mechanobiology, and the pre-clinical evaluation of IVD devices and therapies.
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影响因子：
2.4
作者：
Holsgrove, Timothy P.;Amin, Dhara B.;Costi, John J.
通讯作者：
Costi, John J.
影响因子：
3.7
作者：
Costi JJ;Ledet EH;O'Connell GD
通讯作者：
O'Connell GD
在术后第一个月内对三名患者进行了遥测椎体置换术的负荷测量。
影响因子：
1.8
作者：
A. Rohlmann;F. Graichen;A. Bender;R. Kayser;G. Bergmann
通讯作者：
G. Bergmann
高级多轴脊柱测试：临床相关性和研究建议
DOI：
--
发表时间：
2015
期刊：
The International Journal of Spine Surgery
影响因子：
--
作者：
T. Holsgrove;N. Nayak;W. Welch;B. Winkelstein
通讯作者：
B. Winkelstein
影响因子：
3
作者：
Nguyen, Trang H.;Randolph, David C.;Travis, Russell
通讯作者：
Travis, Russell