Qualitative host factors associated with immunological control of HIV infection by CD8 T cells
Qualitative host factors associated with immunological control of HIV infection by CD8 T cells
复制标题
与 CD8 T 细胞对 HIV 感染的免疫控制相关的定性宿主因素
DOI：
10.1097/01.coh.0000194108.14601.69
复制
发表时间：
2006
影响因子：
4.1
通讯作者：
M. Connors
中科院分区：
文献类型：
--
作者：
S. Migueles;J. Tilton;M. Connors
综述的目的尽管在过去的几年里，重大的技术进步使得对病毒特异性细胞免疫的研究变得越来越定量和详细，但我们对少数非进行性艾滋病毒感染病例的免疫控制的性质以及对大多数未经治疗的慢性感染患者的免疫控制的性质的了解仍然不完整。这篇综述将总结HIV细胞免疫反应积极研究领域中的最新发现和争议点。最近的发现现在认识到，在慢性HIV感染中很容易检测到高频率的病毒特异性CD8T细胞，但不会限制病毒的复制。出于这个原因，人们的注意力已经转移到宿主免疫反应的定性特征上，这些特征可能准确地决定病毒复制的限制。最近描述了进展者HIV特异性CD8T细胞在表型、细胞因子分泌和增殖能力方面的一些质变。摘要鉴于在临床前或临床试验中对大多数疫苗的预期反应是刺激细胞免疫以试图改变疾病进展，了解这些质量特征具有特别重要的意义。进一步的研究可能会为刺激接种疫苗的人的有效免疫、防止在接种疫苗的人感染后失去对病毒复制的控制或在已经感染艾滋病毒的人中诱导持久的免疫控制提供关键信息。
Purpose of reviewDespite significant technical advances that have permitted an increasingly more quantitative and detailed study of virus-specific cellular immunity over the past few years, our understanding of the nature of immunological control in rare cases of non-progressive HIV infection and diminished control in the majority of untreated chronically infected patients remains incomplete. This review will summarize recent findings and points of controversy within areas of active investigation of the cellular immune response to HIV. Recent findingsIt is now appreciated that high frequencies of virus-specific CD8 T cells are readily detectable in chronic HIV infection, but do not restrict viral replication. For this reason, attention has shifted to qualitative features of the host immune response that might accurately determine the restriction of viral replication. A number of qualitative changes in the phenotype, cytokine secretion, and proliferative capacity of HIV-specific CD8 T cells of progressors have recently been described. SummaryGiven that the desired response to the majority of vaccines in pre-clinical or clinical testing is to stimulate cellular immunity in an attempt to alter disease progression, understanding these qualitative features is of particular relevance. Further study will probably yield critical information for the means to stimulate effective immunity in vaccinees, prevent the loss of control of viral replication upon infection of vaccinees, or induce durable immunological control in humans already infected with HIV.
登录
查看更多内容
影响因子：
5.4
作者：
Wherry, EJ;Blattman, JN;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.1073/pnas.050567397
发表时间：
2000-03-14
影响因子：
11.1
作者：
Migueles, SA;Sabbaghian, MS;Connors, M
通讯作者：
Connors, M
影响因子：
120.7
作者：
Davey, RT;Murphy, RL;Kahn, JO
通讯作者：
Kahn, JO
影响因子：
30.5
作者：
Wherry, EJ;Teichgräber, V;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.1073/pnas.94.4.1396
发表时间：
1997-02-18
影响因子：
11.1
作者：
Ferrari, G;Humphrey, W;Weinhold, KJ
通讯作者：
Weinhold, KJ