The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.
The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.
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DOI：
10.1053/j.gastro.2017.07.007
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发表时间：
2017-09
期刊：
影响因子：
29.4
通讯作者：
Fitzgerald RC
中科院分区：
文献类型：
--
作者：
Contino G;Vaughan TL;Whiteman D;Fitzgerald RC
我们最近对决定Barrett‘s食道(BE)和进展为食管腺癌(EA)风险的遗传因素有了前所未有的了解。下一代测序技术使我们能够识别引发BE的体细胞突变，并跟踪肿瘤和浸润性癌症发展过程中的基因变化。这些技术导致了肿瘤发生机制的确定，这些机制挑战了目前向EA进展的多步骤模型。更新、更具成本效益的技术创造了机会，可以迅速将DNA分析转化为工具，可以识别患有癌症高风险的患者，在早期阶段检测发育不良病变，并揭示致癌机制。
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett’s esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multi-step model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions at earlier stages, and uncover mechanisms of carcinogenesis.
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影响因子：
14.9
作者：
An O;Dall'Olio GM;Mourikis TP;Ciccarelli FD
通讯作者：
Ciccarelli FD
影响因子：
6.4
作者：
Dura, Polat;van Veen, Elke M.;Peters, Wilbert H. M.
通讯作者：
Peters, Wilbert H. M.
影响因子：
11.2
作者：
Dulak AM;Schumacher SE;van Lieshout J;Imamura Y;Fox C;Shim B;Ramos AH;Saksena G;Baca SC;Baselga J;Tabernero J;Barretina J;Enzinger PC;Corso G;Roviello F;Lin L;Bandla S;Luketich JD;Pennathur A;Meyerson M;Ogino S;Shivdasani RA;Beer DG;Godfrey TE;Beroukhim R;Bass AJ
通讯作者：
Bass AJ
影响因子：
30.8
作者：
Dulak, Austin M.;Stojanov, Petar;Peng, Shouyong;Lawrence, Michael S.;Fox, Cameron;Stewart, Chip;Bandla, Santhoshi;Imamura, Yu;Schumacher, Steven E.;Shefler, Erica;McKenna, Aaron;Carter, Scott L.;Cibulskis, Kristian;Sivachenko, Andrey;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Auclair, Daniel;Thompson, Kristin;Sougnez, Carrie;Onofrio, Robert C.;Guiducci, Candace;Beroukhim, Rameen;Zhou, Zhongren;Lin, Lin;Lin, Jules;Reddy, Rishindra;Chang, Andrew;Landrenau, Rodney;Pennathur, Arjun;Ogino, Shuji;Luketich, James D.;Golub, Todd R.;Gabriel, Stacey B.;Lander, Eric S.;Beer, David G.;Godfrey, Tony E.;Getz, Gad;Bass, Adam J.
通讯作者：
Bass, Adam J.
影响因子：
28.2
作者：
Agrawal N;Jiao Y;Bettegowda C;Hutfless SM;Wang Y;David S;Cheng Y;Twaddell WS;Latt NL;Shin EJ;Wang LD;Wang L;Yang W;Velculescu VE;Vogelstein B;Papadopoulos N;Kinzler KW;Meltzer SJ
通讯作者：
Meltzer SJ