Brain morphological signatures for chronic pain.
Brain morphological signatures for chronic pain.
复制标题
DOI：
10.1371/journal.pone.0026010
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Apkarian AV
中科院分区：
文献类型：
--
作者：
Baliki MN;Schnitzer TJ;Bauer WR;Apkarian AV
慢性疼痛不仅可以理解为功能状态的改变，而且可以理解为神经元可塑性的结果。在这里，我们使用体内结构MRI来比较慢性背痛（CBP）、复杂区域疼痛综合征（CRPS）和膝关节骨关节炎（OA）患者相对于健康对照组的灰质特性的整体、局部和结构变化。我们发现，不同的慢性疼痛类型表现出独特的解剖“大脑签名”。只有CBP组显示全脑灰质体积改变，而各组的区域灰质密度不同。灰质密度的体素比较显示，对疼痛慢性程度的影响局限于所有条件下的一组共同区域。当灰质密度接近布罗德曼面积的大区域进行检查时，它表现出独特的大规模分布式网络为每个组。我们得出了一个条形码，总结了一个单一的指标内的主题共同变化的灰质密度，这使得个人的大脑分类，以他们的条件具有很高的准确性。该指数还能够计算具有疼痛慢性性的脑重组指数增加的时间常数和渐近幅度，并表明与CRPS相比，CBP中具有疼痛慢性性的脑重组慢6倍，大两倍。结果表明，每种情况下都有丰富的大脑解剖重组，因此反映了不同类型慢性疼痛的独特适应不良生理学。
Chronic pain can be understood not only as an altered functional state, but also as a consequence of neuronal plasticity. Here we use in vivo structural MRI to compare global, local, and architectural changes in gray matter properties in patients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA), relative to healthy controls. We find that different chronic pain types exhibit unique anatomical ‘brain signatures’. Only the CBP group showed altered whole-brain gray matter volume, while regional gray matter density was distinct for each group. Voxel-wise comparison of gray matter density showed that the impact on the extent of chronicity of pain was localized to a common set of regions across all conditions. When gray matter density was examined for large regions approximating Brodmann areas, it exhibited unique large-scale distributed networks for each group. We derived a barcode, summarized by a single index of within-subject co-variation of gray matter density, which enabled classification of individual brains to their conditions with high accuracy. This index also enabled calculating time constants and asymptotic amplitudes for an exponential increase in brain re-organization with pain chronicity, and showed that brain reorganization with pain chronicity was 6 times slower and twice as large in CBP in comparison to CRPS. The results show an exuberance of brain anatomical reorganization peculiar to each condition and as such reflecting the unique maladaptive physiology of different types of chronic pain.
登录
查看更多内容
影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.3
作者：
Kuchinad, Anil;Schweinhardt, Petra;Bushnell, M. Catherine
通讯作者：
Bushnell, M. Catherine
影响因子：
14.5
作者：
Luerding, R.;Weigand, T.;Schmidt-Wilcke, T.
通讯作者：
Schmidt-Wilcke, T.
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR