Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.
Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.
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DOI：
10.1016/j.neuron.2010.03.002
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发表时间：
2010-04-15
期刊：
影响因子：
16.2
通讯作者：
Apkarian, A. Vania
中科院分区：
文献类型：
--
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
我们比较了对照组和慢性背痛（CBP）患者对急性有害热刺激的大脑激活情况。两组的疼痛感知和相关的皮质激活模式相似。然而，伏隔核（NAc）的活动以非常高的准确性区分了两组，表现出具有不同特性的相位性和紧张性反应。在刺激开始和结束时，伏隔核的正相位性激活追踪刺激的显著性，并且在正常受试者中，预测了刺激结束时的奖赏（疼痛缓解）程度。在慢性背痛患者中，伏隔核的活动与正常受试者所涉及的皮质回路不同，并且在刺激结束时的相位性活动极性为负，这表明急性疼痛缓解了持续的背痛。这种缓解作用在针对慢性背痛患者的另一项心理物理学研究中得到了证实。因此，与反映急性有害刺激的感觉特性的躯体感觉通路不同，人类伏隔核的活动编码其预测值，并预测其对慢性疼痛的镇痛潜力。
We compared brain activations in response to acute noxious thermal stimuli in controls and chronic back pain (CBP) patients. Pain perception and related cortical activation patterns were similar in the two groups. However, nucleus accumbens (NAc) activity differentiated the groups at a very high accuracy, exhibiting phasic and tonic responses with distinct properties. Positive phasic NAc activations at stimulus onset and offset tracked stimulus salience and, in normal subjects predicted reward (pain relief) magnitude at stimulus offset. In CBP, NAc activity correlated with different cortical circuitry than normals and phasic activity at stimulus offset was negative in polarity, suggesting that the acute pain relieves the ongoing back pain. The relieving effect was confirmed in a separate psychophysical study in CBP. Therefore, in contrast to somatosensory pathways, which reflect sensory properties of acute noxious stimuli, NAc activity in humans encodes its predicted value and predicts its analgesic potential on chronic pain.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.7
作者：
Carlezon WA Jr;Thomas MJ
通讯作者：
Thomas MJ
影响因子：
5.3
作者：
Baliki, Marwan N.;Chialvo, Dante R.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
25
作者：
Johansen, JP;Fields, HL
通讯作者：
Fields, HL
影响因子：
56.9
作者：
GOEDERS, NE;SMITH, JE
通讯作者：
SMITH, JE